Results 91 to 100 of about 5,144,608 (398)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Digital Inequality and Access by Low-Income Individuals to Public Benefits
Journal of Quantitative Description: Digital MediaThis study presents novel data on digital inequality to describe differences in individuals’ online interactions with public and private sector services.
Jihye Lee +4 more
doaj +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
The Public Trust Doctrine: What a Tall Tale They Tell [PDF]
, 2009 Despite continuing hostility towards the public trust doctrine because of its potential to defeat private property rights and the will of elected representatives, the doctrine refuses to die.
Babcock, Hope M.
core +2 more sources
The Relations between Hope and Subjective Well-Being: a Literature Overview and Empirical Analysis
Applied Research in Quality of Life, 2019 How we perceive the future can greatly affect how we feel in the present. Even a currently positive situation is hard to bear when we know the future will be grim. Indeed, previous research has found that more hopeful people are happier.
E. Pleeging, M. Burger, J. van Exel
semanticscholar +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
The Effect of the United States Supreme Court\u27s Eleventh Amendment Jurisprudence on Clean Water Act Citizen Suits: Muddied Waters [PDF]
, 2004 This Article focuses on the impact of the Court\u27s Eleventh Amendment jurisprudence on citizen suits authorized under the Clean Water Act (CWA), because that law\u27s cooperative federalism structure is typical of many other environmental laws, and ...
Babcock, Hope M.
core +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
The platformisation of party politics?
Journal of Quantitative Description: Digital MediaPolitical parties have gone digital. Political scientists in countries around the world have diagnosed the rise of the digital party and traced parties’ adoption of digital technology.
Kate Dommett +2 more
doaj +1 more source