Results 71 to 80 of about 4,269,411 (306)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

The platformisation of party politics?

open access: yesJournal of Quantitative Description: Digital Media
Political parties have gone digital. Political scientists in countries around the world have diagnosed the rise of the digital party and traced parties’ adoption of digital technology.
Kate Dommett   +2 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

I Hope

open access: yes, 2016
As I have gotten older, I have learned that no matter how hard I try, I am never going to be able to repay my mother for everything that she did for me.
Trinh, Mai
core  

Administering the Clean Water Act: Do Regulators Have Bigger Fish to Fry When it Comes to Addressing the Practice of Chumming on the Chesapeake Bay? [PDF]

open access: yes, 2007
The Chesapeake Bay is one of the country\u27s most productive estuaries. However, for decades the health of the Bay has been declining due in large part to nutrification.
Babcock, Hope M.
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Death of a Platform?

open access: yesJournal of Quantitative Description: Digital Media
While a series of case studies have provided useful insights into the political uses of Twitter, scholars have pointed to the necessity for longitudinal and cross-country findings in order to further our understanding of social media use in this regard.
Anders Olof Larsson
doaj   +1 more source

Coloring Outside The Lines: A Response to Professor Seamon’s Dismantling Monuments [PDF]

open access: yes, 2018
In Dismantling Monuments, Professor Richard H. Seamon defends President Donald Trump’s recent proclamations modifying the boundaries of two national monuments, Grand Staircase-Escalante and Bears Ears, that Presidents Clinton and Obama each designated at
Babcock, Hope M.
core   +1 more source

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