Results 61 to 70 of about 4,269,411 (306)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Proud Boys on Telegram

open access: yesJournal of Quantitative Description: Digital Media
Utilizing an original data set of public Telegram channels affiliated with a right-wing extremist group, the Proud Boys, we conduct an exploratory analysis of the structure and nature of the group’s presence on the platform. Our study considers the group’
Wei Zhong   +3 more
doaj   +1 more source

Putting a Price on Whales To Save Them: What Do Morals Have To Do with It? [PDF]

open access: yes, 2013
The author explores the moral implication of a proposal to create an international market in whale shares as an alternative to the dysfunctional International Whaling Commission.
Babcock, Hope M.
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Should \u3ci\u3eLucas v. South Carolina Coastal Council\u3c/i\u3e Protect Where the Wild Things Are? Of Beavers, Bob-o-Links, and Other Things that Go Bump in the Night [PDF]

open access: yes, 2000
Lucas v. South Carolina Coastal Council is one of several recent Supreme Court decisions in which the Court used the Just Compensation Clause as a weapon of reaction to strike down an offending land use restriction.
Babcock, Hope M.
core   +1 more source

Examining hope as a transdiagnostic mechanism of change across anxiety disorders and CBT treatment protocols. [PDF]

open access: yes, 2020
Hope is a trait that represents the capacity to identify strategies or pathways to achieve goals and the motivation or agency to effectively pursue those pathways.
Barlow, David H.   +6 more
core   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

Digital Inequality and Access by Low-Income Individuals to Public Benefits

open access: yesJournal of Quantitative Description: Digital Media
This study presents novel data on digital inequality to describe differences in individuals’ online interactions with public and private sector services.
Jihye Lee   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Global Climate Change: A Civic Republican Moment for Achieving Broader Changes in Environmental Behavior [PDF]

open access: yes, 2009
These comments were given by Professor Hope Babcock on April 17, 2008 for the fourteenth annual Lloyd K. Garrison Lecture on Environmental Law at Pace Law School.
Babcock, Hope M.
core   +3 more sources

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