Results 41 to 50 of about 1,125,911 (313)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Dialing for Videos: A Random Sample of YouTube

Journal of Quantitative Description: Digital Media, 2023
YouTube is one of the largest, most important communication platforms in the world, but while there is a great deal of research about the site, many of its fundamental characteristics remain unknown. To better understand YouTube as a whole, we created a
Ryan McGrady, Kevin Zheng, Rebecca Curran, Jason Baumgartner, Ethan Zuckerman   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Is there anything Left?: A Global Analysis on Changes in Engagement with Political Content on Twitter in the Musk Era

Journal of Quantitative Description: Digital Media
Over the past few years, Twitter (now X) has become an influential platform for political discourse. However, prior research suggests that Twitter may be biased towards right-wing content.
Brahmani Nutakki, Rosa M. Navarrete, Giuseppe Carteny, Ingmar Weber   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

ElectionRumors2022: A Dataset of Election Rumors on Twitter During the 2022 U.S. Midterms

Journal of Quantitative Description: Digital Media
Understanding the spread of online rumors is a pressing societal challenge and an active area of research across domains. In the context of the 2022 U.S. midterm elections, one influential social media platform for sharing information — including rumors
Joseph Schafer, Kayla Duskin, Stephen Prochaska, Morgan Wack, Anna Beers, Lia Bozarth, Taylor Agajanian, Michael Caulfield, Emma Spiro, Kate Starbird   +9 more
doaj   +1 more source

Value for Correction: Documenting Perceptions about Peer Correction of Misinformation on Social Media in the Context of COVID-19

Journal of Quantitative Description: Digital Media, 2021
Although correction is often suggested as a tool against misinformation, and empirical research suggests it can be an effective one, we know little about how people perceive the act of correcting people on social media.
Leticia Bode, Emily Vraga
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Who Does(n't) Target You?

Journal of Quantitative Description: Digital Media
Political campaigns are increasingly investing in targeted advertising on social media platforms to reach voters. Despite critical implications for citizens and elections, little is known about the targeting strategies deployed by political parties ...
Fabio Votta, Simon Kruschinski, Mads Hove, Natali Helberger, Tom Dobber, Claes de Vreese   +5 more
doaj   +1 more source