Results 71 to 80 of about 384,646 (364)

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Evolution of substrate specificity in a recipient's enzyme following horizontal gene transfer [PDF]

, 2013
Despite the prominent role of horizontal gene transfer (HGT) in shaping bacterial metabolism, little is known about the impact of HGT on the evolution of enzyme function.
Abascal, Aldo R. Camacho-Zarco, Barona-Gomez, Brune, Carver, Collaborative Computational Project, Number 4 (CCP4), Dean, Depristo, Des Marais, Dittmar, Due, Francisco Barona-Gómez, Glykos, Guindon, Henn-Sax, Hess, Hodgson, Hu, Hughes, Humphrey, Ikeda, James, Jensen, Jensen, Jones, Jorgensen, Jung, Kane, Klassen, Kuper, Leaver-Fay, Lerat, Lianet Noda-García, MacKerell, Mauricio Carrillo-Tripp, McCoy, Murshudov, Nester, Noda-Garcia, Ohno, Pal, Parish, Paul Gaytán, Perrakis, Piatigorsky, Sofía Medina-Ruíz, Sterner, Tokuriki, Tokuriki, Treangen, Vilmos Fülöp, Vriend, Wright, Xie, Xie   +54 more
core   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Horizontal gene transfer in human pathogens. [PDF]

, 2015
This is the accepted version of the original publication available at http://informahealthcare.com/doi/abs/10.3109/1040841X.2013.804031.Horizontal gene transfer has a tremendous impact on the genome plasticity, adaptation and evolution of bacteria ...
Juhas, Mario
core  

Modeling, Simulation and Application of Bacterial Transduction in Genetic Algorithms [PDF]

, 2009
At present, all methods in Evolutionary Computation are bioinspired in the fundamental principles of neo-Darwinism as well as on a vertical gene transfer. Thus, on a mechanism in which an organism receives genetic material from its ancestor.
Carlos Perales-Gravan, Javier de Vicente Buendia, Rafael Lahoz-Beltra   +2 more
core   +2 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Horizontal transfer, not duplication, drives the expansion of protein families in prokaryotes. [PDF]

PLoS Genetics, 2011
Gene duplication followed by neo- or sub-functionalization deeply impacts the evolution of protein families and is regarded as the main source of adaptive functional novelty in eukaryotes.
Todd J Treangen, Eduardo P C Rocha
doaj   +1 more source

Inferring multiple consensus trees and supertrees using clustering: a review [PDF]

arXiv, 2023
Phylogenetic trees (i.e. evolutionary trees, additive trees or X-trees) play a key role in the processes of modeling and representing species evolution. Genome evolution of a given group of species is usually modeled by a species phylogenetic tree that represents the main patterns of vertical descent. However, the evolution of each gene is unique.
arxiv  

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Updated clusters of orthologous genes for Archaea: a complex ancestor of the Archaea and the byways of horizontal gene transfer

Biology Direct, 2012
Background Collections of Clusters of Orthologous Genes (COGs) provide indispensable tools for comparative genomic analysis, evolutionary reconstruction and functional annotation of new genomes.
Wolf Yuri I, Makarova Kira S, Yutin Natalya, Koonin Eugene V   +3 more
doaj   +1 more source