Results 71 to 80 of about 596,709 (329)

CRISPR-Cas systems restrict horizontal gene transfer in Pseudomonas aeruginosa

The ISME Journal, 2020
CRISPR-Cas systems provide bacteria and archaea with an adaptive immune system that targets foreign DNA. However, the xenogenic nature of immunity provided by CRISPR-Cas raises the possibility that these systems may constrain horizontal gene transfer ...
Rachel M. Wheatley, R. MacLean
semanticscholar   +1 more source

The early phase of a bacterial insertion sequence infection [PDF]

, 2010
Bacterial insertion sequences are the simplest form of autonomous mobile DNA. It is unknown whether they need to have beneficial effects to infect and persist in bacterial populations, or whether horizontal gene transfer suffices for their persistence ...
Andreas Wagner, Andrew D. Barbour, Athreya, Basten, Berg, Bergthorsson, Blot, Chandler, Charlesworth, Dahlberg, Dawkins, Doolittle, Dröge, Egner, Feller, Fisher, Galas, Gibbons, Gogarten, Haccou, Haldane, Hall, Harris, Jagers, Jiang, Johnson, Kendall, Kimmel, Kimura, Kleckner, Manuel Bichsel, Mayaux, McClintock, Moody, Moran, Nuzhdin, Ohta, Orgel, Powell, R Development Core Team, Savageau, Sawyer, Schneider, Sewastjanow, Shapiro, So, Sørensen, Tavakoli, Thompson, Top, Touchon, Wagner, Wagner, Williams, Zerbib   +54 more
core   +1 more source

Horizontal Gene Transfer in Eukaryotes: Not if, but How Much?

Trends in Genetics, 2020
Horizontal gene transfer (HGT), the movement of genetic material across branches of the tree of life, is well established in prokaryotes and uncontroversial.
Julia Van Etten, D. Bhattacharya
semanticscholar   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Horizontal gene transfer of microbial cellulases into nematode genomes is associated with functional assimilation and gene turnover

BMC Evolutionary Biology, 2011
Background Natural acquisition of novel genes from other organisms by horizontal or lateral gene transfer is well established for microorganisms. There is now growing evidence that horizontal gene transfer also plays important roles in the evolution of ...
Dieterich Christoph, Bartelmes Gabi, Schuster Lisa N, Mayer Werner E, Sommer Ralf J   +4 more
doaj   +1 more source

Metacommunity structure preserves genome diversity in the presence of gene-specific selective sweeps under moderate rates of horizontal gene transfer.

PLoS Computational Biology, 2023
The horizontal transfer of genes is fundamental for the eco-evolutionary dynamics of microbial communities, such as oceanic plankton, soil, and the human microbiome.
Simone Pompei, Edoardo Bella, Joshua S Weitz, Jacopo Grilli, Marco Cosentino Lagomarsino   +4 more
doaj   +1 more source

Massive Horizontal Gene Transfer in Bdelloid Rotifers [PDF]

, 2008
Horizontal gene transfer in metazoans has been documented in only a few species and is usually associated with endosymbiosis or parasitism. By contrast, in bdelloid rotifers we found many genes that appear to have originated in bacteria, fungi, and ...
Arkhipova, Irina, Gladyshev, Evgeniy, Meselson, Matthew   +2 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Horizontal gene transfer contributes to plant evolution : the case of Agrobacterium T-DNAs [PDF]

, 2017
Horizontal gene transfer (HGT) can be defined as the acquisition of genetic material from another organism without being its offspring. HGT is common in the microbial world including archaea and bacteria, where HGT mechanisms are widely understood and ...
Gheysen, Godelieve, Kreuze, Jan F, Quispe Huamanquispe, Dora   +2 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source