Results 21 to 30 of about 779,949 (313)

Horizontal Well Productivity Evaluation for Stress Sensitive Elliptical Reservoirs

open access: yesImproved Oil and Gas Recovery, 2020
Well productivity model is one of the vital tools required to evaluate well performance. Most horizontal well productivity models are idealistic in nature, mainly developed for homogeneous reservoirs and conventional reservoirs, and ignore the influences
Weidong Tian, Zhenzhen Dong, Jiaen Lin
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Application of Reaming Drill Bit in Horizontal Directional Well

open access: yesMeikuang Anquan, 2020
The reaming drill bit wrapped with mud in long-distance horizontal directional well will lead to drilling time delay and trajectory deviation from the original wellbore.
LI Peng, MO Haitao, ZHANG Qiang, LI Zijian
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

HORIZONTAL WELL DRILL-IN FLUIDS

open access: yesRudarsko-geološko-naftni Zbornik, 1998
Main objective of horizontal driling is to place a drain-hole for a long distance within the pay zone to enhance productivity or injectivity. In drilling horizontal wells, more serious problems appear than in drilling vertical wells.
Nediljka Gaurina-Međimurec
doaj  

Economic and productivity evaluation of different horizontal drilling scenarios: Middle East oil fields as case study

open access: yesJournal of Petroleum Exploration and Production Technology, 2019
Development of high-density oil and gas fields presents a great challenge to the energy industry due to the low productivity of individual wells and their high drilling cost.
Abbas Khaksar Manshad   +6 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

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