Results 41 to 50 of about 15,241,235 (285)
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Design of a Leap-type Horizontal Well Tractor
Shiyou jixie, 2018 To address the problems of wheeled horizontal well tractor like poor obstacle crossing ability and solo obstacle crossing way, a structural design of a leap-type horizontal well obstacle-crossing tractor was proposed by studying the obstacle-crossing ...
Chen Liangfan, Gao Deli
doaj
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
HORIZONTAL MERGERS FOR BUYER POWER [PDF]
Salant et al. (1983) showed in a Cournot setting that horizontal mergers are unprofitable because outsiders react by increasing their output. We show that this negative effect may be compensated by the positive effect that horizontal mergers have on the ...
Lluís Bru Martínez +1 more
core +2 more sources
Modeling of Inflow Well Performance of Multilateral Wells: Employing the Concept of Well Interference and the Joshi's Expression [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2011 The use of multilateral well is becoming an emerging method to improve oil recovery efficiently and to drain reservoirs more efficacious. By developing drilling technology, completing the oil wells as multilateral wells become more interesting especially
Seyed Reza Shadizadeh +2 more
doaj
FEATURES OF WELL TEST INTERPRETATION RESULTS IN HORIZONTAL WELLS
Известия высших учебных заведений: Нефть и газ, 2018 The article explores the features of well test interpretation results of oil and gas horizontal wells in the southern Iraqi fields. The author pays attention to the deconvolution method during processing the results of studying horizontal wells.
M. J. Alsheikhly, Sh. J. Mirboboev
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Application of Long Lateral Section Horizontal Well Drilling Technology in Well ZC1
Shiyou jixie, 2017 The Well ZC1 has a long horizontal section with the target reservoir of Chang 6. To address the issues like shallow buried depth of Chang 6 reservoir, long horizontal section and open hole section, difficulty in wellbore cleaning and stability of ...
Tang Honglin +3 more
doaj
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source