Results 41 to 50 of about 886,828 (304)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Decoupled overlapping grids for the numerical modeling of oil wells
, 2012 Accurate computation of time-dependent well bore pressure is important in well test analysis - a branch of petroleum engineering where reservoir properties are estimated by comparing measured pressure responses at an oil well to results from a ...
Dugald B. Duncan +3 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
FEATURES OF WELL TEST INTERPRETATION RESULTS IN HORIZONTAL WELLS
Известия высших учебных заведений: Нефть и газ, 2018 The article explores the features of well test interpretation results of oil and gas horizontal wells in the southern Iraqi fields. The author pays attention to the deconvolution method during processing the results of studying horizontal wells.
M. J. Alsheikhly, Sh. J. Mirboboev
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Classical Horizontal Inequity and Reranking: an Integrated Approach [PDF]
The last 20 years have seen a significant evolution in the literature on horizontal inequity (HI) and have led to two major and "rival" methodological strands, namely, classical HI and reranking.
Jalbert, Vincent +2 more
core +2 more sources
Prediction of Sidetrack Horizontal Well Extension Length
Shiyou jixie, 2016 The study on the slim hole sidetrack horizontal well extending length limit could help to determine the design and operating parameters for sidetrack horizontal well as well as the drilling technologies.Considering the characteristics of slim hole ...
Wang Jianlong +5 more
doaj
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Design of a Leap-type Horizontal Well Tractor
Shiyou jixie, 2018 To address the problems of wheeled horizontal well tractor like poor obstacle crossing ability and solo obstacle crossing way, a structural design of a leap-type horizontal well obstacle-crossing tractor was proposed by studying the obstacle-crossing ...
Chen Liangfan, Gao Deli
doaj
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source