Results 51 to 60 of about 891,157 (304)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Productivity Index of Horizontal Gas Well [PDF]
, 2017 One of the most direct techniques to evaluate gas well production capacity is by productivity index (PI). As the application of horizontal wells has significantly increased since 1980s, a number of correlations for predicting the horizontal well PI have ...
Almuraikhi, Abdullah A.
core +2 more sources
Production Behavior Analysis of Multibranched Horizontal Oil Well considering Reservoir and Well-Type Factors [PDF]
, 2022 Multibranched horizontal well is an important means to develop low permeability reservoirs. Fishbone multibranched horizontal well has the advantages of increasing drainage area, reducing drilling number, utilizing existing wells, and saving oilfield ...
Xiaoxiao Sun +4 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Dominant Flow Mechanisms in Falling-Film and Droplet Mode Evaporation Over Horizontal Rectangular Tube Banks [PDF]
, 2012 Flow visualization with high-speed video of evaporating water films falling over flat horizontal tubes, representative of the external surfaces of microchannel tubes, is presented.
Garimella, Srinivas, Bustamante, John G.
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Classical Horizontal Inequity and Reranking: an Integrated Approach [PDF]
The last 20 years have seen a significant evolution in the literature on horizontal inequity (HI) and have led to two major and "rival" methodological strands, namely, classical HI and reranking.
Jalbert, Vincent +2 more
core +3 more sources
Prediction of Sidetrack Horizontal Well Extension Length
Shiyou jixie, 2016 The study on the slim hole sidetrack horizontal well extending length limit could help to determine the design and operating parameters for sidetrack horizontal well as well as the drilling technologies.Considering the characteristics of slim hole ...
Wang Jianlong +5 more
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Mechanics Analysis on Horizontal Well Tractor System
Shiyou jixie, 2016 The dynamic performance of horizontal well tractor directly influence the tractor’s work quality,so mechanics studies on tractor are essential.But the traditional tractor mechanics study methods are usually simple.To build a more accurate model of ...
Chen Liangfan, Gao Deli, Zhao Ning
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