Results 31 to 40 of about 782,217 (265)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

FEATURES OF WELL TEST INTERPRETATION RESULTS IN HORIZONTAL WELLS

open access: yesИзвестия высших учебных заведений: Нефть и газ, 2018
The article explores the features of well test interpretation results of oil and gas horizontal wells in the southern Iraqi fields. The author pays attention to the deconvolution method during processing the results of studying horizontal wells.
M. J. Alsheikhly, Sh. J. Mirboboev
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Prediction of Sidetrack Horizontal Well Extension Length

open access: yesShiyou jixie, 2016
The study on the slim hole sidetrack horizontal well extending length limit could help to determine the design and operating parameters for sidetrack horizontal well as well as the drilling technologies.Considering the characteristics of slim hole ...
Wang Jianlong   +5 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Design of a Leap-type Horizontal Well Tractor

open access: yesShiyou jixie, 2018
To address the problems of wheeled horizontal well tractor like poor obstacle crossing ability and solo obstacle crossing way, a structural design of a leap-type horizontal well obstacle-crossing tractor was proposed by studying the obstacle-crossing ...
Chen Liangfan, Gao Deli
doaj  

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

open access: yesFEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso   +4 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Mechanics Analysis on Horizontal Well Tractor System

open access: yesShiyou jixie, 2016
The dynamic performance of horizontal well tractor directly influence the tractor’s work quality,so mechanics studies on tractor are essential.But the traditional tractor mechanics study methods are usually simple.To build a more accurate model of ...
Chen Liangfan, Gao Deli, Zhao Ning
doaj  

Selection and Optimization of Drilling Equipment for CBM Horizontal Well

open access: yesMeikuang Anquan, 2020
In order to meet the construction requirements of CBM horizontal well and reduce the drilling cost, it is necessary to investigate and summarize the conventional water-source drilling rig, oil drilling rig and truck-mounted drilling rig.
YANG Zhe
doaj   +1 more source

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