Results 31 to 40 of about 779,949 (313)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Anti-collision Technology of Horizontal Well Groups in Shale Gas “Well Factory”
Shiyou jixie, 2016 With the widely applied "well factory" drilling model in shale gas development,the traditional calculation method of well trajectory distance and WdW error model can no longer meet the requirement of the wellbore anti-collision.For wireless MWD tool,the ...
Liu Maosen, Fu Jianhong, Bai Jing
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Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
FEATURES OF WELL TEST INTERPRETATION RESULTS IN HORIZONTAL WELLS
Известия высших учебных заведений: Нефть и газ, 2018 The article explores the features of well test interpretation results of oil and gas horizontal wells in the southern Iraqi fields. The author pays attention to the deconvolution method during processing the results of studying horizontal wells.
M. J. Alsheikhly, Sh. J. Mirboboev
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Prediction of Sidetrack Horizontal Well Extension Length
Shiyou jixie, 2016 The study on the slim hole sidetrack horizontal well extending length limit could help to determine the design and operating parameters for sidetrack horizontal well as well as the drilling technologies.Considering the characteristics of slim hole ...
Wang Jianlong +5 more
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Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Design of a Leap-type Horizontal Well Tractor
Shiyou jixie, 2018 To address the problems of wheeled horizontal well tractor like poor obstacle crossing ability and solo obstacle crossing way, a structural design of a leap-type horizontal well obstacle-crossing tractor was proposed by studying the obstacle-crossing ...
Chen Liangfan, Gao Deli
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