Results 61 to 70 of about 3,820 (294)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Perception of Horizontality as a Function of Age and Stimulus Setting

, 1967
Esbtimation of horizontality was tested by having three groups of 43 Ss in the first and third grades and first year college draw the water surface on pictures of tilted glasses, simulating a half-filled condition.
Daniel C. O'Connell, James D. Barna
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Measuring the Organisational Horizontality in Argentinian Software SMEs: The “Worker Ownership – Horizontality of Management” Scale

Based upon economic democracy conceptions, and taking organisational management as its central dimension, the article has a twofold purpose. Firstly, it proposes a conceptual elucidation for “horizontality of management”, a construct that represents the ...
Estrago, Alfonso Manuel
core   +1 more source

Interpreting horizontality. Minor centers, intervention strategies and sustainable development

Techne, 2019
This paper presents the results of a research carried out within the framework of an Agreement between the Department of Architecture of the University of Naples Federico II and the Municipality of Aquilonia (AV).
Mariangela Bellomo, Angela D'Agostino
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Management styles in Argentina’s software SMEs: from diversity to horizontality [PDF]

, 2023
El artículo presenta los resultados de una investigación doctoral, de carácter exploratoria-descriptiva, centrada en la indagación de los diversos estilos de gestión observables en PyME del sector software de Argentina, con particular atención sobre ...
Estrago, Alfonso Manuel
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Supervariable Approach to the Nilpotent Symmetries for a Toy Model of the Hodge Theory

Advances in High Energy Physics, 2016
We exploit the standard techniques of the supervariable approach to derive the nilpotent Becchi-Rouet-Stora-Tyutin (BRST) and anti-BRST symmetry transformations for a toy model of the Hodge theory (i.e., a rigid rotor) and provide the geometrical meaning
D. Shukla, T. Bhanja, R. P. Malik
doaj   +1 more source