Results 81 to 90 of about 3,820 (294)
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Judgments of Horizontality of Still Water: Effects of Perceptual and Cognitive Factors
, 1988 Three experiments examined failure to solve the Piagetian water-level horizontality task in terms of artifacts of experimental procedure, perceptual characteristics of the task, and the physical principles involved in the task.
S. David Leonard, Hajime Otani
core +1 more source
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
Verticality and horizontality control during the construction phase of the volcanic ash storage silo of the thermoelectric power station - Termozipa [PDF]
, 2019 Controlar la verticalidad y horizontalidad de una estructura (silo), en el proceso de construcción.Control the verticality and horizontality of a structure (silo), in the construction process.William Fernando Olaya ...
Olaya Macias, William Fernando
core
Horizontality and Impossibility in Kafka\u27s Parabolic Quests [PDF]
, 2012 In his article Horizontality and Impossibility in Kafka\u27s Parabolic Quests Frank W. Stevenson explores a horizontal-parabolic interpretation of several Kafka narratives.
Frank W. Stevenson, Stevenson, Frank W.
core +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Knowing Which Way Is Up: Sex Differences In Understanding Horizontality And Verticality [PDF]
, 1992 In previous research men have been shown to obtain higher mean scores on tests of horizontality (H) and verticality (V) than do women. This study investigated the role of experiential factors in this gender difference.
Goodrich, Gary A.
core +1 more source