Results 241 to 250 of about 377,752 (312)

Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of Salmonella Infection

Advanced Science, EarlyView.
To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun, Seoyeon Kim, Seonggyu Kim, Minsoo Noh, Dae‐Kyum Kim, Eun‐Jin Lee, Hunsang Lee   +6 more
wiley   +1 more source

Digital Rehabilitation Program for Breast Cancer Survivors on Adjuvant Hormonal Therapy: A Feasibility Study. [PDF]

Cancers (Basel)
Chan WL, Wong YL, Tai YL, Liu M, Yun B, Zhang Y, Hou HL, Kwong D, Lee VH, Lam WW.   +9 more
europepmc   +1 more source

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

Management of Endometriosis-Related Pain: Comparing the Effectiveness of Hormonal Therapy, Surgical Interventions, and Complementary Therapies. [PDF]

Cureus
Al Hussaini HAD, Alatawi ESE, Shabani JAJ, Edhrabooh MIH, Alhawaj SAA, Almahfoodh MS, Alsamiri HY, AlMaatoug AR, Hayderali MIM, Almousa MR.   +9 more
europepmc   +1 more source

Risk factors for late bowel and bladder toxicities in NRG Oncology prostate cancer trials of high-risk patients: A meta-analysis of physician-rated toxicities [PDF]

, 2018
et al,, Michalski, Jeff M
core   +1 more source

Magnesium Structure‐Function Integration Platform for Spatiotemporal Multi‐Modality Therapy: Combining Hormonotherapy and Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
The schematic illustration of the MHSCG platform for spatiotemporal responsive GRb1 release to induce androgen deprivation therapy (ADT) and immunogenic cell death (ICD) multimodal therapy in prostate cancer. Abstract Metal‐based immunotherapy represents a promising strategy for enhancing antitumor efficacy; however, its clinical application is limited
Rui Zan, Qianping Mao, Keyi Wang, Guodong Zou, Shi Yang, Hua Qiu, Xiang Fang, Guiqing Wang, Xinyi Zhou, Jiexia Wen, Shuai Jiang, Ran Huang, Qiuming Peng, Tao Suo   +13 more
wiley   +1 more source

Efficacy and Safety of Chemotherapy Combined with Hormonal Therapy in Heavily Pretreated Advanced Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (ELSA/KGOG3049): A Multicenter Pilot Study. [PDF]

Cancers (Basel)
Kim K, Choi CH, Park SY, Kim MK, Lee KH, Lee EJ, Lim MC, Park YH, Kyung MS, No JH, Suh DH, Lee JW, Ahn S, Lee B.   +13 more
europepmc   +1 more source

Heavy Menstrual Bleeding and Hormonal Therapy in Women with Type 1 von Willebrand Disease Enrolled on the Zimmerman Program. [PDF]

Clin Appl Thromb Hemost
Machin N, Navarrete A, Rothenberger S, Flood V, Christopherson P, Montgomery R, Ragni MV, Zimmerman Program Investigators.   +7 more
europepmc   +1 more source

Prognostic value of pathological sensitivity for high-risk, localized prostate cancer receiving neoadjuvant hormonal therapy combined with radical prostatectomy. [PDF]

Ann Med
Shi K, Chen S, Wang X, Wang W, Zhu Y, Han B, Wang Y, Shi B.   +7 more
europepmc   +1 more source

Effectiveness of Hormonal Therapy for Post-Menopausal Women with Hormone Receptor-Positive Advanced Breast Cancer: A Systematic Review and Meta-Analysis of Clinical Trials. [PDF]

Med Princ Pract
Okwor VC, Okwor JC, Ukwuoma MK, Mitha SB, Nweke MC.   +4 more
europepmc   +1 more source