Results 251 to 260 of about 5,588,761 (314)

Associations between PIK3CA Mutations and Disease Free Survival in Patients with HR+, HER2− Tumors Treated with Adjuvant Hormonal Therapy: A Real‐World Study in Croatia

Dora Čerina, Natalija Dedić Plavetić, Ingrid Belac-Lovasić, Robert Šeparović, Josipa Flam, Marija Pancirov, Žarko Bajić, Snježana Tomić, Eduard Vrdoljak   +8 more
openalex   +1 more source

ERβ/circAHNAK Axis Inhibits USP10–FMR1 Deubiquitination to Prevent m⁶A‐Mediated ADAM17 Decay and Promote Angiogenesis in Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In clear cell renal cell carcinoma, estrogen receptor β (ERβ) upregulates circAHNAK, which competitively binds USP10 to prevent FMR1 deubiquitination, leading to FMR1 degradation. Loss of FMR1 hinders m⁶A‐dependent decay of ADAM17 mRNA, resulting in ADAM17 accumulation in tumor exosomes and enhanced angiogenesis.
Chao Xu, Sujing Zhang, Yuepeng Liu, Jingwei Lv, Yilong Cao, Yao Chen, Hao Sun, Bowei Zhang, Shengtao Dai, Jiehan Li, Xiaoling Li, Bei Shi, Qingyun Sun, Meng Zhu, Junfei Gu   +14 more
wiley   +1 more source

Digital Rehabilitation Program for Breast Cancer Survivors on Adjuvant Hormonal Therapy: A Feasibility Study. [PDF]

Cancers (Basel)
Chan WL, Wong YL, Tai YL, Liu M, Yun B, Zhang Y, Hou HL, Kwong D, Lee VH, Lam WW.   +9 more
europepmc   +1 more source

Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation

Advanced Science, EarlyView.
Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Zhiguo Li, Huiyi Quan, Wanting Liu, Jiaoling Chen, Mengyang Chu, Xin Tang, Ke Xue, Xuan Liu, Jingyi Ma, Yaxing Bai, Ruina Dong, Bing Li, Junfeng Hao, Wei Guo, Qingyang Li, Erle Dang, Johann E Gudjonsson, Gang Wang, Shuai Shao   +18 more
wiley   +1 more source

Management of Endometriosis-Related Pain: Comparing the Effectiveness of Hormonal Therapy, Surgical Interventions, and Complementary Therapies. [PDF]

Cureus
Al Hussaini HAD, Alatawi ESE, Shabani JAJ, Edhrabooh MIH, Alhawaj SAA, Almahfoodh MS, Alsamiri HY, AlMaatoug AR, Hayderali MIM, Almousa MR.   +9 more
europepmc   +1 more source

Nutritional c‐Fos Induction Rewires Hepatic Metabolism and Can Promote Obesity‐Associated Hepatocellular Carcinoma

Advanced Science, EarlyView.
It is shown that hepatic c‐Fos responds to feeding, altering de novo lipogenesis, glycolysis, and a wide range of steatosis‐associated metabolic signaling pathways. Obesogenic diets cause hepatic c‐Fos overexpression, insulin resistance, and the induction of metabolic reprogramming‐related genes.
Ao Li, Eduardo H. Gilglioni, Wadsen St‐Pierre‐Wijckmans, Leila Hosseinzadeh, Christelle Veyrat‐Durebex, Sumeet Pal Singh, Roberto Coppari, Latifa Bakiri, Esteban N. Gurzov   +8 more
wiley   +1 more source

Efficacy and Safety of Chemotherapy Combined with Hormonal Therapy in Heavily Pretreated Advanced Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (ELSA/KGOG3049): A Multicenter Pilot Study. [PDF]

Cancers (Basel)
Kim K, Choi CH, Park SY, Kim MK, Lee KH, Lee EJ, Lim MC, Park YH, Kyung MS, No JH, Suh DH, Lee JW, Ahn S, Lee B.   +13 more
europepmc   +1 more source

Menopausal hormone therapy and incidence, mortality, and survival of breast cancer subtypes: a prospective cohort study

Marit Busund, Giske Ursin, Eiliv Lund, S Chen, Charlotta Rylander   +4 more
openalex   +1 more source

ARL3 Enhances ERα Stability via USP10 Deubiquitination to Promote Endocrine Resistance and Drive Mitochondrial Metabolic Reprogramming in HR+ Breast Cancer

Advanced Science, EarlyView.
This study identifies ADP‐ribosylation factor‐like protein 3 (ARL3) as a novel chaperone that stabilizes estrogen receptor α (ERα) in breast cancer. ARL3 promotes tumor growth by recruiting USP10 to remove ubiquitin chains from ERα, preventing its degradation.
Han Li, Yang Liu, Zehao Cai, Kang Li, Shun Gao, Ailin Lan, Dan Shu, Kuan He, Xin Liu, Yang Peng, Shipeng Guo, Haochen Yu, Aishun Jin, Meiying Shen, Shengchun Liu   +14 more
wiley   +1 more source

Gene therapy with feline anti-Müllerian hormone analogs disrupts folliculogenesis and induces pregnancy loss in female domestic cats

William A. Stocker, Lauren Olenick, Shreya Maskey, Denise Skrombolas, Haitong Luan, Sophie G. Harrison, Matthew Wilson, Anne M. Traas, Mark Heffernan, Samantha J. Busfield, Kelly L. Walton, Craig A. Harrison   +11 more
openalex   +1 more source