Results 21 to 30 of about 5,588,761 (314)

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance Increasing evidence suggests that extracellular vesicles (EVs) can transfer genetic material to recipient cells. However, the mechanism and role of this phenomenon are largely unknown. Here we have made a remarkable discovery: EVs can harbor
P. Sansone, C. Savini, I. Kurelac, Q. Chang, Laura Benedetta Amato, Antonio Strillacci, Anna Stepanova, L. Iommarini, C. Mastroleo, L. Daly, A. Galkin, B. K. Thakur, Nadine Soplop, K. Uryu, Ayuko Hoshino, L. Norton, M. Bonafè, M. Cricca, G. Gasparre, D. Lyden, J. Bromberg   +20 more
semanticscholar   +1 more source

Hormone therapy in the management of prostate cancer: evidence-based approaches

Therapeutic Advances in Urology, 2010
Hormonal therapy has been the standard for advanced prostate cancer for over 60 years. Recently, the utility of androgen ablation through various means has been demonstrated for earlier stages of disease.
Leonard G. Gomella, Jaspreet Singh, Costas Lallas, Edouard J. Trabulsi   +3 more
doaj   +1 more source

Hormonal Therapy Resistance and Breast Cancer: Involvement of Adipocytes and Leptin

Nutrients, 2019
Obesity, a recognized risk factor for breast cancer in postmenopausal women, is associated with higher mortality rates regardless of menopausal status, which could in part be explained by therapeutic escape.
L. Delort, L. Bougaret, J. Cholet, Marion Vermerie, H. Billard, C. Decombat, C. Bourgne, M. Berger, C. Dumontet, F. Caldefie-Chézet   +9 more
semanticscholar   +1 more source

Salvage pembrolizumab added to kinase inhibitor therapy for the treatment of anaplastic thyroid carcinoma

Journal for ImmunoTherapy of Cancer, 2018
Background Anaplastic thyroid carcinoma (ATC) is a rare but deadly form of thyroid cancer. Kinase inhibitors kinase inhibitors have shown clinical efficacy in the management of ATC, however, eventually these tumors acquire resistance to KI and patients ...
Priyanka C. Iyer, Ramona Dadu, Maria Gule-Monroe, Naifa L. Busaidy, Renata Ferrarotto, Mouhammed Amir Habra, Mark Zafereo, Michelle D. Williams, G. Brandon Gunn, Horiana Grosu, Heath D. Skinner, Erich M. Sturgis, Neil Gross, Maria E. Cabanillas   +13 more
doaj   +1 more source

Gene-Based Therapy: A New Approach to Feline Induced Sterilization?

Future Pharmacology, 2023
Feline population control remains a concern as to whether it is intended for the short- or long-term. Induced sterilization of felids is critical in the case of feral, free-roaming cats, or the management of wild populations in Zoos or sanctuaries.
Rita Payan-Carreira
doaj   +1 more source

OVERALL AND CANCER-SPECIFIC SURVIVAL OF HIGH-RISK PROSTATE CANCER – IMPACT OF ADJUVANT THERAPY AFTER RADICAL PROSTATECTOMY [PDF]

Journal of IMAB, 2023
Purpose: The study examines the survival of patients with high-risk prostate cancer in order to find a relationship between survival and the type of postoperative therapy.
Tosho Ganev
doaj   +1 more source

Spermatogenesis Abnormalities following Hormonal Therapy in Transwomen

BioMed Research International, 2018
Objective To measure spermatogenesis abnormalities in transwomen at the time of sex reassignment surgery (SRS) and to analyze the association between hormonal therapy duration and infertility severity. Design Retrospective study.
S. Jindarak, Kasama Nilprapha, T. Atikankul, A. Angspatt, Pornthep Pungrasmi, Seree Iamphongsai, Pasu Promniyom, P. Suwajo, G. Selvaggi, Preecha Tiewtranon   +9 more
semanticscholar   +1 more source

Hormonal therapy is effective and safe for cryptorchidism caused by idiopathic hypogonadotropic hypogonadism in adult males

Frontiers in Endocrinology, 2023
BackgroundHormonal therapy is a reasonable treatment for cryptorchidism caused by idiopathic hypogonadotropic hypogonadism (IHH). However, the clinical evidence on whether it is effective and safe for the treatment of cryptorchidism caused by IHH is ...
Taotao Sun, Taotao Sun, Wenchao Xu, Wenchao Xu, Hao Xu, Hao Xu, Yinwei Chen, Yonghua Niu, Daoqi Wang, Tao Wang, Tao Wang, Weimin Yang, Weimin Yang, Jihong Liu, Jihong Liu   +14 more
doaj   +1 more source

Transgender women, hormonal therapy and HIV treatment: a comprehensive review of the literature and recommendations for best practices

Journal of the International AIDS Society, 2016
Studies have shown that transgender women (TGW) are disproportionately affected by HIV, with an estimated HIV prevalence of 19.1% among TGW worldwide.
A. Radix, J. Sevelius, M. Deutsch
semanticscholar   +1 more source

Menopausal hormonal therapy or non-hormonal treatment: rational choice [PDF]

Гинекология, 2015
Patients with the "climacteric syndrome" diagnosis make only 1,0% in structure of the general incidence of the women who visit the female consultation, and 1.6% - total of the patients consisting on the dispensary account.
T Yu Pestrikova, E A Yurasova, T V Yachinskaya, T D Kovalyova   +3 more
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