Basal Glucose Control in Type 1 Diabetes using Deep Reinforcement Learning: An In Silico Validation [PDF]
IEEE journal of biomedical and health informatics 2020, 2020 People with Type 1 diabetes (T1D) require regular exogenous infusion of insulin to maintain their blood glucose concentration in a therapeutically adequate target range. Although the artificial pancreas and continuous glucose monitoring have been proven to be effective in achieving closed-loop control, significant challenges still remain due to the ...
arxiv +1 more source
Low-fat diets and testosterone in men: Systematic review and meta-analysis of intervention studies [PDF]
The Journal of steroid biochemistry and molecular biology (2021)
210: 105878, 2022 Background: Higher endogenous testosterone levels are associated with reduced chronic disease risk and mortality. Since the mid-20th century, there have been significant changes in dietary patterns, and men's testosterone levels have declined in western countries.
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Hormonal Factors Moderate the Associations Between Vascular Risk Factors and White Matter Hyperintensities [PDF]
arXiv, 2022 Objective: To examine the moderation effects of hormonal factors on the associations between vascular risk factors and white matter hyperintensities (WMH) in men and women, separately. Methods: WMH were automatically segmented and quantified in the UK Biobank dataset (N = 18,294). Generalised linear models were applied to examine 1) the main effects of
arxiv
Unbinding of Retinoic Acid from its Receptor Studied by Steered Molecular Dynamics [PDF]
Biophysical Journal 76, 188 (1999), 1999 Retinoic acid receptor (RAR) is a ligand-dependent transcription factor that regulates the expression of genes involved in cell growth, differentiation, and development. Binding of the retinoic acid hormone to RAR is accompanied by conformational changes in the protein which induce transactivation or transrepression of the target genes.
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Label-free assaying of testosterone and growth hormones in blood using surface-enhanced raman spectroscopy [PDF]
arXiv, 2023 This work reports the potential use of surface enhanced Raman spectroscopy (SERS) in rapid, label-free assaying of testosterone (TE) and growth hormone (GH) in whole blood. Biomarker SERS spectral bands from the two hormones (TE and GH) in intentionally spiked water for injection and in male Sprague-Dawley (SD) rat blood are reported.
arxiv
Design Principles of Pancreatic Islets: Glucose-dependent Coordination of Hormone Pulses [PDF]
PLoS ONE 11(4):e0152446 (2016), 2015 Pancreatic islets are functional units involved in glucose homeostasis. The multicellular system comprises three main cell types; $\beta$ and $\alpha$ cells reciprocally decrease and increase blood glucose by producing insulin and glucagon pulses, while the role of $\delta$ cells is less clear.
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Orlicz hormonic Blaschke addition [PDF]
arXiv, 2021 Recently, Gardner, Hug and Weil have introduced the Orlicz-Brunn-Minkowski theory: a general framework, additions, and inequalities. Following this, in the paper we consider Orlicz dual Brunn-Minkowski theory. We introduce Orlicz hormonic Blaschke addition which is an extension of the Lp hormonic Blaschke addition and L p radial Minkowski addition ...
arxiv
Modeling of mouse experiments suggests that optimal anti-hormonal treatment for breast cancer is diet-dependent [PDF]
arXiv, 2023 Estrogen receptor positive breast cancer is frequently treated with anti-hormonal treatment such as aromatase inhibitors (AI). Interestingly, a high body mass index has been shown to have a negative impact on AI efficacy, most likely due to disturbances in steroid metabolism and adipokine production.
arxiv
On the Hardness of Problems Involving Negator Relationships in an Artificial Hormone System [PDF]
arXiv, 2020 The Artificial Hormone System (AHS) is a self-organizing middleware to allocate tasks in a distributed system. We extended it by so-called negator hormones to enable conditional task structures. However, this extension increases the computational complexity of seemingly simple decision problems in the system: In [1] and [2], we defined the problems ...
arxiv
Human Luteinizing Hormone and Chorionic Gonadotropin Display Biased Agonism at the LH and LH/CG Receptors [PDF]
Scientific Reports, 7(940) (2017), 2018 Human luteinizing hormone (LH) and chorionic gonadotropin (hCG) have been considered biologically equivalent because of their structural similarities and their binding to the same receptor; the LH/CGR. However, accumulating evidence suggest that LH/CGR differentially responds to the two hormones triggering differential intracellular signaling and ...
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