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Protective Activities of Growth Hormone-Releasing Hormone Antagonists against Toxin-Induced Endothelial Injury [PDF]
EndocrinesGHRH regulates the secretion of GH from the anterior pituitary gland, previously associated with cancer progression and inflammation. An emerging body of evidence suggests that GHRHAnt support endothelial barrier function, but the mechanisms mediating ...
Saikat Fakir, Nektarios Barabutis
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Neural Regeneration Research, 2022 Both inflammation and anti-inflammation are involved in the protection of retinal cells. Antagonists of the hypothalamic growth hormone-releasing hormone receptor (GHRHR) have been shown to possess potent anti-inflammatory properties in experimental ...
Ling-Ping Cen +3 more
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Androgen deprivation therapy and side effects: are GnRH antagonists safer?
Asian Journal of Andrology, 2021 Androgen deprivation therapy (ADT) with gonadotropin-releasing hormone (GnRH) agonists and antagonists is the mainstay of advanced prostate cancer treatment. Both drug classes decrease levels of luteinizing hormone and follicle-stimulating hormones (FSH),
Stephen J Freedland +1 more
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Impact of Androgen Deprivation Therapy on Cardiovascular Outcomes in Prostate Cancer
Société Internationale d’Urologie Journal, 2022 PurposeSubstantial evidence indicates that men with prostate cancer are at an increased risk for cardiovascular disease, and medical and surgical androgen deprivation therapy is associated with further increased cardiovascular risk. There are conflicting
Laurence Klotz +3 more
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Luteinizing hormone-releasing hormone antagonists [PDF]
Expert Opinion on Therapeutic Patents, 2009 Luteinizing hormone-releasing hormone (LH-RH) plays a central role in the vertebrate reproduction by regulating gonadal activity. Based on its binding to pituitary LH-RH receptors, as well as to LH-RH receptors expressed on cancer cells, LH-RH agonists and antagonists have been developed for different therapeutic applications.Here we give an overview ...
Mezö, Gábor, Manea, Marilena
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Mistaken administration of a repeat loading dose of Degarelix leading to acute psychosis
JRSM Open, 2021 Lesson Advanced and metastatic prostate cancer is often managed with hormonal blockage. Luteinising hormone-releasing hormone antagonists achieve rapid testosterone suppression and are used for the treatment of advanced or metastatic prostate cancer ...
Musaab Hamdoon +3 more
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F&S Reports, 2023 Gonadotropin-releasing hormone (GnRH) is central to the control of the entire hypothalamic-pituitary-gonadal axis. Manipulation of GnRH, in turn, regulates pituitary response and ovarian hormone production.
Farrah L. Saleh, M.D. +1 more
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Recent Development of Non-Peptide GnRH Antagonists
Molecules, 2017 The decapeptide gonadotropin-releasing hormone, also referred to as luteinizing hormone-releasing hormone with the sequence (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) plays an important role in regulating the reproductive system.
Feng-Ling Tukun +5 more
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Preparation and Characterization of an Antibody Antagonist That Targets the Porcine Growth Hormone Receptor [PDF]
Asian-Australasian Journal of Animal Sciences, 2016 A series of antagonists specifically targeting growth hormone receptors (GHR) in different species, such as humans, rats, bovines, and mice, have been designed; however, there are currently no antagonists that target the porcine growth hormone (GH ...
Huanzhong Cui +3 more
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Gonadotropin-releasing hormone analogs: Understanding advantages and limitations
Journal of Human Reproductive Sciences, 2014 Pituitary stimulation with pulsatile gonadotropin-releasing hormone (GnRH) analogs induces both follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Pratap Kumar, Alok Sharma
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