Results 91 to 100 of about 561,014 (300)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Gonadotropin-Releasing Hormone Antagonists-A New Hope in Endometriosis Treatment? [PDF]

J Clin Med, 2023
Rzewuska AM, Żybowska M, Sajkiewicz I, Spiechowicz I, Żak K, Abramiuk M, Kułak K, Tarkowski R.   +7 more
europepmc   +1 more source

Mechanisms of synergism between antagonists of growth hormone‐releasing hormone and antagonists of luteinizing hormone‐releasing hormone in shrinking experimental benign prostatic hyperplasia

, 2013
BACKGROUND Benign prostatic hyperplasia (BPH) affects aging men. Combined therapy with antagonists of growth hormone‐releasing hormone (GHRH) and of luteinizing hormone‐releasing hormone (LHRH or GnRH) induces prostate shrinkage in rat models.
Block, Norman L, Abi‐Chaker, Andrew, Krishan, Awtar, Ferenc G. Rick, Schally, Andrew V, Szalontay, Luca, Andrew V. Schally, Awtar Krishan, Andrew Abi‐Chaker, Rick, Ferenc G, Norman L. Block, Luca Szalontay   +11 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Identification of specific reference gene for normalization of RT-qPCR data in rhythmic gene expression studies of the effect of developmental hormone antagonist in postembryonic development in Bombyx mori

Frontiers in Insect Science
Bombyx mori is a lepidopteran holometabolous insect with distinct developmental stages: egg, larvae, pupae, and adult. The lepidopteran insect undergoes major modifications in the central nervous system (CNS) so as to adapt to the lifestyle of these ...
Minurani Dalai, Anita Jagota
doaj   +1 more source

Apo-ghrelin receptor (apo-GHSR1a) Regulates Dopamine Signaling in the Brain

Frontiers in Endocrinology, 2014
The orexigenic peptide hormone ghrelin is synthesized in the stomach and its receptor growth hormone secretagogue receptor (GHSR1a) is expressed mainly in the central nervous system (CNS).
Andras eKern, Cristina eGrande, Roy G Smith   +2 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Luteinising hormone-releasing hormone antagonists in prostate cancer therapy

, 2007
The introduction of androgen blockade therapy using luteinising hormone-releasing hormone (LHRH)/gonadotropin-releasing hormone analogues alone or in combination with non-steroidal antiandrogens has a major impact in both survival and quality of life of ...
Diamanti, E., Koutsilieris, M., Tzanela, M., Msaouel, P.   +3 more
core   +1 more source

The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 72-78).The activation of Gonadotropin-releasing hormone receptor (GnRHR) by the GnRH ligand has been shown to mediate antiproliferative effects in extra-pituitary cells and in reproductive ...
Phillips, Pumza Samantha
core   +1 more source

Ovarian sensitivity index affects clinical pregnancy and live birth rates in gonadotropin-releasing hormone agonist and antagonist in vitro fertilization cycles

Frontiers in Endocrinology
ObjectivesThis study aimed to investigate the correlation of ovarian sensitivity index (OSI) and clinical parameters in IVF treatments.MethodsIVF data files between January 2011 and December 2020 in a single unit were included.
Chao Chin Hsu, Chao Chin Hsu, Isabel Hsu, Sonam Dorjee, Yi Chun Chen, Tzu Ning Chen, Yu Lin Chuang   +6 more
doaj   +1 more source