Results 71 to 80 of about 561,014 (300)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Growth hormone-releasing hormone receptor antagonists modify molecular machinery in the progression of prostate cancer [PDF]

, 2018
Background: Therapeutic strategies should be designed to transform aggressive prostate cancer phenotypes to a chronic situation. To evaluate the effects of the new growth hormone-releasing hormone receptor (GHRH-R) antagonists: MIA-602, MIA-606, and MIA ...
Ana M. Bajo, Schally, Andrew Victor, Juan C. Prieto, Andrew V. Schally, Carmena Sierra, María José, Bajo, Ana M, Muñoz Moreno, Laura, Prieto Villapún, Juan Carlos, Bajo Chueca, Ana María, Muñoz-Moreno, Laura, M. José Carmena, Schally, Andrew V, Carmena, M. José, Laura Muñoz-Moreno, Prieto, Juan C   +14 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Investigating the role of growth hormone receptor in oesophageal squamous-cell carcinoma. [PDF]

, 2013
Includes abstract.Includes bibliographical references.Squamous-cell carcinoma of the oesophagus is a formidable disease which poses a significant health risk in developing countries where incidence is high and survival is low.
Boris Krivochiev, Krivochiev, Boris
core   +1 more source

The Effect of Androgen Deprivation Therapy on the Cardiovascular System in Advanced Prostate Cancer

Medicina
Androgen deprivation therapy (ADT) is a mainstay treatment for metastatic prostate cancer, improving progression-free survival. ADT suppresses the production of testosterone and reduces circulating levels of the hormone.
Allison B. Reiss, Samantha Vasalani, Jacqueline Albert, Wendy Drewes, Kathleen Li, Ankita Srivastava, Joshua De Leon, Aaron E. Katz   +7 more
doaj   +1 more source

Stimulation of growth hormone by kisspeptin antagonists in ewes [PDF]

, 2018
Kisspeptin signalling is indispensable for fertility, stimulating gonadotropin- releasing hormone (GnRH) secretion and mediating gonadal steroid feedback on GnRH neurons.
M Millar, Millar, Michael, Millar, M, Smith, Jeremy T., Millar, R P, Roseweir, Antonia, Millar, Robert P., Roseweir, A, A Roseweir, I J Clarke, Clarke, Iain, Clarke, I J, R P Millar, Smith, J T, J T Smith   +14 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

DEGARELIX ROLE AND PLACE IN THE COMBINED TREATMENT OF PATIENTS WITH PROSTATE CANCER IN COMBINATION WITH CONCURRENT RADIOTHERAPY

Сибирский онкологический журнал, 2016
Application Degarelix ADT patients who underwent combined radiotherapy, already on the first results showed the high efficiency and low toxicity. For patients with localized prostate cancer with intermediate factors and a poor prognosis, as well as for ...
A. Y. Pavlov, R. A. Gafanov, S. V. Fastovets, A. D. Tsybulsky, T. K. Isaev   +4 more
doaj  

In vitro fertilization results of GNRH antagonists and medroxyprogesterone acetate used to prevent premature LH surge during ovarian hyperstimulation

Scientific Reports
The aim of this study was to evaluate the effects of medroxyprogesterone acetate (MPA) treatment in comparison to those of gonadotropin releasing hormone (GnRH) antagonists for the prevention of premature luteinizing hormone surges during controlled ...
Can Dinç, Saltuk Buğra Arıkan, Mustafa Özer, Şafak Olgan   +3 more
doaj   +1 more source