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Antagonists of Growth Hormone-Releasing Hormone in Oncology
Combinatorial Chemistry & High Throughput Screening, 2006 The development of antagonists of growth hormone (GH) - releasing hormone (GH-RH) is reviewed. GH-RH antagonists bind with a high affinity to pituitary receptors for GH-RH and inhibit the release of GH in vitro and in vivo. The main applications of GH-RH antagonists would be for tumor therapy.
Andrew V, Schally, Jozsef L, Varga
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Growth Hormone-Releasing Hormone Antagonists Inhibit Growth of Human Ovarian Cancer
Hormone and Metabolic Research, 2011 Epithelial ovarian carcinoma is the leading cause of cancer-related deaths among women with gynecologic malignancies. Antagonists of the growth hormone-releasing hormone (GHRH) have been shown to inhibit growth of various cancers through endocrine ...
Ferenc Rick, Andrea Papadia, M Zarandi
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Inhibitory Effects of Antagonists of Growth Hormone-Releasing Hormone (GHRH) in Thyroid Cancer
Hormones and Cancer, 2017 Growth hormone-releasing hormone (GHRH) is a peptide hormone secreted by the hypothalamus that regulates the synthesis and secretion of growth hormone (GH) in the pituitary. The extra-hypothalamic GHRH and its cognate receptors (GHRHR and splice variants)
Leandro Miranda-Alves +2 more
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Growth Hormone Receptor Antagonists
Neuroendocrinology, 2006The currently available long-acting somatostatin analogs normalize serum growth hormone (GH) levels and insulin-like growth factor-I levels in approximately 60% of patients with acromegaly. The recently introduced GH receptor antagonist, pegvisomant, is able to normalize insulin-like growth factor-I levels in virtually all acromegalic subjects ...
van der Lely, AJ (Aart-Jan) +1 more
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Antagonists of Trophic Hormones
Gynecologic and Obstetric Investigation, 2010Antagonists of pituitary trophic hormones may act either by inhibiting the synthesis and release of the hormone, by interfering with the interaction of the trophic hormone with its target tissue, or by inhibiting the intracellular response of the target cell.
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Steroid Hormones, Receptors, and Antagonists
Annals of the New York Academy of Sciences, 1996In the thirty-odd years since the first demonstration of estrogen-binding components in reproductive tissues, much has been learned about the molecular details of steroid hormone action. Facts still to be elucidated include the precise mechanism by which interaction with the steroid disrupts the native receptor complex to generate an active ...
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The future of growth hormone antagonists
Current Opinion in Pharmacology, 2002Pegvisomant is the only available member of a new class of drugs: the growth hormone receptor antagonists. It has a proven efficacy in antagonising the effects of growth hormone in acromegalic patients that is better than any of the currently available treatment modalities.
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Antagonists of the Neurohypophysial Hormones
1968Throughout the history of pharmacology the exploration of antagonism and the use of antagonists has played an important role both in the development of theoretical concepts and interpretations and in experimental practice. The use of antagonists to interfere with the physiological or pathological effects of endogenous mediators forms an important ...
J. Rudinger, I. Krejčí
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Luteinizing hormone–releasing hormone antagonists in prostate cancer
Urology, 2001Luteinizing hormone-releasing hormone (LHRH) antagonists work by directly inhibiting LHRH without any initial stimulation of the LHRH receptor. The physiologic response is a direct and rapid decrease in luteinizing hormone, follicle-stimulating hormone, and testosterone without any flare.
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