Results 281 to 290 of about 136,105 (353)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Drug-Induced Osteoporosis. [PDF]

J Clin Med
Gasser RW, Kocijan R, Zendeli A, Resch H.   +3 more
europepmc   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Precision pharmacology in menopause: advances, challenges, and future innovations for personalized management. [PDF]

Front Reprod Health
Guo ZQ.
europepmc   +1 more source

KNDy neurons as an indirect target of insulin-like growth factor-1. [PDF]

J Neuroendocrinol
Silva JDN, de Sousa LMM, de Sousa ME, Vieira HR, Alves GA, Neifert NT, Moore AM, Donato J, Frazao R.   +8 more
europepmc   +1 more source

Diagnostic and Therapeutic Potential of Substance P/NK1 Receptor in Primary Dysmenorrhea: A Pilot Study. [PDF]

Health Sci Rep
Mehboob R, Shahid I, Alzahrani AR, Yousof SM, Adnan H, Ekram SN, Alwazzan A, Nasief H, Khadawardi KA.   +8 more
europepmc   +1 more source

Association Between Long-term Use of H₂ Receptor Antagonists and Prostate Cancer Risk: A Case-Control Study in Taiwan. [PDF]

J Cancer
Wang SF, Liu YC, Nguyen PA, Lin GL, Huang CW, Rahmanti AR, Yang HC.   +6 more
europepmc   +1 more source

Production of human growth hormone antagonist (hGHG120R) in Chinese hamster ovary cells

, 1997
Raj Haldankar
openalex   +1 more source