Results 281 to 290 of about 1,678,607 (395)

Precision pharmacology in menopause: advances, challenges, and future innovations for personalized management. [PDF]

Front Reprod Health
Guo ZQ.
europepmc   +1 more source

Plant Robotics for Sustainable and Environmentally Friendly Robots: Insights from Actuation Characteristics

Advanced Science, EarlyView.
Plants are promising materials for building sustainable and eco‐friendly robots due to their inherent multifunctionality, with actuation playing a crucial role. This article focuses on the physical movements of plants and, from the perspective of actuation characteristics, explores representative plant species and their behaviors, the current state of ...
Kazuya Murakami, Misao Sato, Yu Ikeda, Tatsuhiro Horii, Yukari Nagatoshi, Miki Fujita, Toshinori Fujie, Yasunari Fujita, Jun Shintake   +8 more
wiley   +1 more source

KNDy neurons as an indirect target of insulin-like growth factor-1. [PDF]

J Neuroendocrinol
Silva JDN, de Sousa LMM, de Sousa ME, Vieira HR, Alves GA, Neifert NT, Moore AM, Donato J, Frazao R.   +8 more
europepmc   +1 more source

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

Diagnostic and Therapeutic Potential of Substance P/NK1 Receptor in Primary Dysmenorrhea: A Pilot Study. [PDF]

Health Sci Rep
Mehboob R, Shahid I, Alzahrani AR, Yousof SM, Adnan H, Ekram SN, Alwazzan A, Nasief H, Khadawardi KA.   +8 more
europepmc   +1 more source

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

Advanced Science, EarlyView.
Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
wiley   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Association Between Long-term Use of H₂ Receptor Antagonists and Prostate Cancer Risk: A Case-Control Study in Taiwan. [PDF]

J Cancer
Wang SF, Liu YC, Nguyen PA, Lin GL, Huang CW, Rahmanti AR, Yang HC.   +6 more
europepmc   +1 more source

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

Somatostatin analogs in endothelial dysfunction. [PDF]

Am J Physiol Endocrinol Metab
Barabutis N.
europepmc   +1 more source