Results 291 to 300 of about 136,105 (353)

Growth Hormone Receptor Antagonists

Neuroendocrinology, 2006
The currently available long-acting somatostatin analogs normalize serum growth hormone (GH) levels and insulin-like growth factor-I levels in approximately 60% of patients with acromegaly. The recently introduced GH receptor antagonist, pegvisomant, is able to normalize insulin-like growth factor-I levels in virtually all acromegalic subjects ...
van der Lely, AJ (Aart-Jan), Kopchick, JJ   +1 more
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Gonadotropin-releasing-hormone-receptor antagonists

The Lancet, 2001
Pulsatile gonadotropin-releasing hormone (GnRH) stimulates the pituitary secretion of both luteinising hormone (LH) and follicle-stimulating hormone (FSH) and thus controls the hormonal and reproductive function of the gonads. Blockade of GnRH effects may be wanted for a variety of reasons-eg, to prevent untimely luteinisation during assisted ...
J A, Huirne, C B, Lambalk
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Calcium Antagonists and Hormone Release

Clinical Science, 1984
Introduction: Calcium (Ca2+) has been aptly entitled the ‘universal provocateur’ [1] in recognition of its many indispensable metabolic actions. The class of drugs popularly known as calcium antagonists (calcium slow channel blockers) provokes a variety of pharmacological effects and these drugs are useful as probes of calcium-dependent mechanisms. One
Millar, J. A., Struthers, A. D.
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Antagonists of Growth Hormone-Releasing Hormone in Oncology

Combinatorial Chemistry & High Throughput Screening, 2006
The development of antagonists of growth hormone (GH) - releasing hormone (GH-RH) is reviewed. GH-RH antagonists bind with a high affinity to pituitary receptors for GH-RH and inhibit the release of GH in vitro and in vivo. The main applications of GH-RH antagonists would be for tumor therapy.
Andrew V, Schally, Jozsef L, Varga
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Combining Growth Hormone-Releasing Hormone Antagonist With Luteinizing Hormone-Releasing Hormone Antagonist Greatly Augments Benign Prostatic Hyperplasia Shrinkage

Journal of Urology, 2012
Benign prostatic hyperplasia often affects aging men. Antagonists of the neuropeptide growth hormone-releasing hormone reduced prostate weight in an androgen induced benign prostatic hyperplasia model in rats. Luteinizing hormone-releasing hormone antagonists also produce marked, protracted improvement in lower urinary tract symptoms, reduced prostate ...
Ferenc G, Rick, Luca, Szalontay, Andrew V, Schally, Norman L, Block, Mehrdad, Nadji, Karoly, Szepeshazi, Irving, Vidaurre, Marta, Zarandi, Magdolna, Kovacs, Zoltan, Rekasi   +9 more
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Antagonists of Trophic Hormones

Gynecologic and Obstetric Investigation, 1971
Antagonists of pituitary trophic hormones may act either by inhibiting the synthesis and release of the hormone, by interfering with the interaction of the trophic hormone with its target tissue, or by inhibiting the intracellular response of the target cell.
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Steroid Hormones, Receptors, and Antagonists

Annals of the New York Academy of Sciences, 1996
In the thirty-odd years since the first demonstration of estrogen-binding components in reproductive tissues, much has been learned about the molecular details of steroid hormone action. Facts still to be elucidated include the precise mechanism by which interaction with the steroid disrupts the native receptor complex to generate an active ...
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