Results 301 to 310 of about 136,105 (353)
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Luteinizing hormone–releasing hormone antagonists in prostate cancer
Urology, 2001Luteinizing hormone-releasing hormone (LHRH) antagonists work by directly inhibiting LHRH without any initial stimulation of the LHRH receptor. The physiologic response is a direct and rapid decrease in luteinizing hormone, follicle-stimulating hormone, and testosterone without any flare.
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Growth hormone secretagogue receptor antagonists.
Expert opinion on therapeutic patents, 2012The patent claims peptidic/nonpeptidic inhibitors of the ghrelin receptor, the growth hormone secretagogue receptor (GHSR) 1A. Among these compounds, it was disclosed that the addition in some compounds of a GlyMetAla tripeptide at the N-terminus of the ghrelin peptide agonists converts them into ghrelin receptor antagonists.
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Antineoplastic Action of Growth Hormone-Releasing Hormone (GHRH) Antagonists
Recent Patents on Anti-Cancer Drug Discovery, 2012Some of the antagonists of growth hormone-releasing hormone (GHRH) are able to inhibit the growth of various experimental human cancers. The antitumor effects of first antagonists seemed to be dependent mainly on the disruption of pituitary secretion of growth hormone (GH), followed by the reduction in the levels of circulating insulin-like growth ...
Agnieszka, Siejka +5 more
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Luteinizing Hormone-releasing Hormone Antagonists in Gynecology
2003The elucidation of the structure of LHRH in 1971 (Serially et al., 1971), a major breakthrough in endocrinology, was soon followed by the synthesis of LHRH superagonists (Karten and Rivier, 1986), which were more stable to cleavage and showed greater affinity to the LHRH receptor, mainly through amino acid substitutions at positions 6 and 10 of the ...
J. B. Engel, K. Diedrich
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Parathyroid Hormone Antagonists Effective in Vivo
1986There has long been great impetus for preparing peptide hormone antagonists effective in vivo. Pure hormone antagonists can be used to determine the mechanism of action of peptide hormones and to elucidate both the role of a hormone in normal physiology and its contribution to pathophysiology.
L H, Caporale, M, Rosenblatt
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The future of growth hormone antagonists
Current Opinion in Pharmacology, 2002Pegvisomant is the only available member of a new class of drugs: the growth hormone receptor antagonists. It has a proven efficacy in antagonising the effects of growth hormone in acromegalic patients that is better than any of the currently available treatment modalities.
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Optimizing gonadotrophin-releasing hormone antagonist protocols
Human Fertility, 2002The introduction of the gonadotrophin-releasing hormone(GnRH) antagonists offers new potential for in vitro fertilization (IVF) clinics. Compared with GnRH agonists, the use of the GnRH antagonists significantly reduces the dose of gonadotrophin and duration of treatment required, and also reduces unwanted side-effects.
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Growth hormone receptor antagonists.
Minerva endocrinologica, 2003Growth hormone (GH) has profound effects on vertebrate growth and cellular differentiation in diverse tissue types. Sexually dimorphic levels of circulating GH vary during development and throughout the lifespan. The synthesis and secretion of GH by the pituitary gland are precisely controlled.
D T, Kohn, J-J, Kopchick
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