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Luteinizing Hormone-releasing Hormone Antagonists in Gynecology
2003The elucidation of the structure of LHRH in 1971 (Serially et al., 1971), a major breakthrough in endocrinology, was soon followed by the synthesis of LHRH superagonists (Karten and Rivier, 1986), which were more stable to cleavage and showed greater affinity to the LHRH receptor, mainly through amino acid substitutions at positions 6 and 10 of the ...
J. B. Engel, K. Diedrich
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Parathyroid Hormone Antagonists Effective in Vivo
1986There has long been great impetus for preparing peptide hormone antagonists effective in vivo. Pure hormone antagonists can be used to determine the mechanism of action of peptide hormones and to elucidate both the role of a hormone in normal physiology and its contribution to pathophysiology.
L H, Caporale, M, Rosenblatt
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The future of growth hormone antagonists
Current Opinion in Pharmacology, 2002Pegvisomant is the only available member of a new class of drugs: the growth hormone receptor antagonists. It has a proven efficacy in antagonising the effects of growth hormone in acromegalic patients that is better than any of the currently available treatment modalities.
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Optimizing gonadotrophin-releasing hormone antagonist protocols
Human Fertility, 2002The introduction of the gonadotrophin-releasing hormone(GnRH) antagonists offers new potential for in vitro fertilization (IVF) clinics. Compared with GnRH agonists, the use of the GnRH antagonists significantly reduces the dose of gonadotrophin and duration of treatment required, and also reduces unwanted side-effects.
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Growth hormone receptor antagonists.
Minerva endocrinologica, 2003Growth hormone (GH) has profound effects on vertebrate growth and cellular differentiation in diverse tissue types. Sexually dimorphic levels of circulating GH vary during development and throughout the lifespan. The synthesis and secretion of GH by the pituitary gland are precisely controlled.
D T, Kohn, J-J, Kopchick
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Gonadotropin-Releasing Hormone Antagonists for Assisted Reproductive Techniques
Drugs, 2012G. Griesinger +3 more
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