Fezolinetant - a potential alternative to hormone replacement therapy for menopausal women
Dear Editor, Menopause is a significant milestone in a woman's life, marking the end of the reproductive cycle due to the depletion of all the ovarian follicles.
Hassan Mehmood+2 more
doaj +1 more source
Confounding-Robust Policy Improvement [PDF]
We study the problem of learning personalized decision policies from observational data while accounting for possible unobserved confounding. Previous approaches, which assume unconfoundedness, i.e., that no unobserved confounders affect both the treatment assignment as well as outcome, can lead to policies that introduce harm rather than benefit when ...
arxiv
A time-resolved fluorescence immunoassay for the measurement of testosterone in saliva: Monitoring of testosterone replacement therapy with testosterone buciclate [PDF]
Monitoring of testosterone replacement therapy requires a reliable method for testosterone measurement. Determination of salivary testosterone, which reflects the hormone's biologically active plasma fraction, is a superior technique for this purpose ...
Bals-Pratsch M+13 more
core +1 more source
Implantable biosensors hold the promise to revolutionize the way disease diagnosis and progression during treatment are viewed. However, in the current state of art, their efficiency is limited by certain material challenges. Porous Silicon (pSi) is a viable material for in vivo monitoring of biomarkers, and its potential as an implantable biosensor is
Pritam Sharma+4 more
wiley +1 more source
HORMONE REPLACEMENT THERAPY AND VENOUS THROMBOEMBOLISM
BACKGROUND Oral hormone replacement therapy (HRT) is associated with 2- to 4-fold increased riskof venous thromboembolism (VTE). Therefore, all women commencing HRT should becounselled about the risk of VTE, signs and symptoms of VTE and measures for ...
Nina Vene
doaj
Hormone replacement therapy and the prevention of postmenopausal osteoporosis
Fracture prevention is one of the public health priorities worldwide. Estrogen deficiency is the major factor in the pathogenesis of postmenopausal osteoporosis, the most common metabolic bone disease.
Marco Gambacciani, Marco Levancini
doaj +1 more source
Effect of tibolone on breast cancer cell proliferation in postmenopausal ER+ patients: Results from STEM trial [PDF]
Purpose: Tibolone is a selective tissue estrogenic activity regulator, approved for the treatment of vasomotor symptoms in postmenopausal women. We have done an exploratory, double-blind, randomized, placebo-controlled pilot trial to investigate the ...
Dowsett, Mitch+10 more
core +2 more sources
This study presents a robust 3D simulation for BBMC, focusing on both fixed and receding receiver scenarios across various conditions. Key parameters such as D, Q, u, and d are tested at different values to assess the performance and reliability of BBMC in applications like drug delivery, addressing critical challenges in nanoscale communication with ...
Mustafa Ozan Duman+3 more
wiley +1 more source
Different effects of oral and transdermal hormone replacement therapies on Factor IX, APC resistance, t-PA, PAI and C- reactive protein - a cross-sectional population survey [PDF]
The effects of hormone replacement therapy (HRT) on thrombosis risk, thrombotic variables, and the inflammatory marker C- reactive protein (CRP) may vary by route of administration (oral versus transdermal).
Lowe, G.D.O.+5 more
core
Accelerated Bone Healing via Electrical Stimulation
Electrical stimulation significantly impacts bone healing by enhancing osteoblast proliferation, differentiation, and vascularization through calmodulin/calcineurin/NFAT signaling. It also boosts macrophage function and cell migration, presenting a comprehensive approach to accelerating bone repair.
Jianfeng Sun+4 more
wiley +1 more source