Results 211 to 220 of about 125,967 (307)

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

Angewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne, Sona Krajcovicova, Graeme Davies, Hannah Bolt, Jefferson Revell, David R. Spring   +5 more
wiley   +2 more sources

Hormone Replacement Therapy and Cardiovascular Health in Postmenopausal Women. [PDF]

Int J Mol Sci
Xia W, Khalil RA.
europepmc   +1 more source

Chrysin alleviates pressure overload–induced myocardial remodeling through regulating the PI3K/AKT/NRF2 pathway–mediated oxidative stress response

Animal Models and Experimental Medicine, EarlyView.
In this study, we primarily simulated pathological myocardial remodeling induced by transverse aortic constriction surgery and found significant cardiac hypertrophy and fibrosis, characterized by deteriorated cardiac function. Oxidative stress response is considered as a pivotal pathological process, which contributes to inflammation and apoptosis of ...
Yijia Wang, Xing Feng, Shuhui Zhao, Yuchong Fu, Ao Zhang, Xiaofeng Shen, Bowen Yu, Yihao Wang, Jiahui Lin, Bing Zhang, Weiping Ji, Lianpin Wu, Xiaoling Guo   +12 more
wiley   +1 more source

Daidzein and Genistein: Natural Phytoestrogens with Potential Applications in Hormone Replacement Therapy. [PDF]

Int J Mol Sci
Intharuksa A, Arunotayanun W, Na Takuathung M, Chaichit S, Prasansuklab A, Chaikhong K, Sirichanchuen B, Chupradit S, Koonrungsesomboon N.   +8 more
europepmc   +1 more source

Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human‐relevant translation

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract shows how molecular biology research has shifted from using traditional animal models toward using methods that are more relevant to humans. It points out the main problems, differences between species, difficulty in reproducing results, moral issues, and lack of infrastructure that make translational accuracy harder to achieve ...
Md. Shajid Hossain Rafi, Md. Taslim Sarker, Ferdous‐Ul‐Haque Joy, Shahriar Mohd Shams, Tahmina Foyez, Md. Abdul Mazid, Syed Masudur Rahman Dewan   +6 more
wiley   +1 more source

The impact of gonadotropin-releasing hormone agonist and hormone replacement therapy in placement of hormone replacement therapy on outcomes of IVF after hysteroscopic polypectomy

Taiwanese Journal of Obstetrics & Gynecology
Yiu-Tai Li, Szu-Ting Yang, Peng-Hui Wang
doaj   +1 more source

Hormone replacement therapy in female-specific cancer survivors: considerations beyond cancer cure. [PDF]

Jpn J Clin Oncol
Yoshihama T, Yokota M, Aoki D, Yamagami W.   +3 more
europepmc   +1 more source

The Impact of Estrogen Deficiency on Liver Metabolism: Implications for Hormone Replacement Therapy.

Endocr Rev
Dong J, Dennis KMJH, Venkatakrishnan R, Hodson L, Tomlinson JW.   +4 more
europepmc   +1 more source

Micronized Vaginal Progesterone Dose and Serum Progesterone Thresholds Determine Reproductive Outcomes in Frozen-Thawed Embryo Transfer With Hormone Replacement Therapy. [PDF]

Reprod Med Biol
Sekiguchi M, Ito A, Katagiri Y, Yoneyama M, Tsuchiya T, Furui M, Umemura N, Kobayashi H, Nakata M.   +8 more
europepmc   +1 more source

An Agonist/Antagonist Photo‐Switchable Vitamin D Mimetic Enables Bidirectional Optical Control of VDR

Angewandte Chemie International Edition, EarlyView.
Vitamin D exhibits complex and cell‐specific biological effects in multiple tissues via activation of the ligand‐sensing transcription factor vitamin D receptor (VDR). The photo‐switchable vitamin D mimetic 10 transitions between VDR antagonist (E) and agonist (Z) activity upon illumination and offers unprecedented bidirectional optical control over ...
Xiu Ge, Sabine Willems, Francesco Melfi, Tufan Mukhopadhyay, Johannes Morstein, Jordan Artzy, Loris Knümann, Giorgia Sbriccoli, Jörg Pabel, Julian A. Marschner, Dirk Trauner, Daniel Merk   +11 more
wiley   +1 more source