Results 111 to 120 of about 3,110,681 (290)
Pharmacological aspects of postmenopausal hormone replacement therapy
, 2022 Post-menopausal hormone replacement therapy has its benefits and risks just like the other substances in pharmacological field. When the women experience menopause-related symptoms, it can be considered as beneficial to initiate HRT if close to the time ...
Iida, Rino
core
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
OSTEOPOROSIS AND HORMONE REPLACEMENT THERAPY
Zdravniški Vestnik, 2008 BACKGROUND Osteoporosis affects almost every other woman after menopause. Fractures due to osteoporosis are a significant cause of disability and death, therefore we try to prevent themwith antiosteoporotic medications.Hormone replacement therapy (HRT ...
Tomaž Kocjan, Damir Franić
doaj
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Growth hormone (GH) provocation tests and the response to GH treatment in GH deficiency [PDF]
, 2004 Objective: To identify factors, particularly the growth hormone (GH) provocation test result, affecting growth response to GH treatment in children with GH deficiency (GHD).Subjects: A total of 337 prepubertal GHD patients aged,10 years from the UK ...
Hindmarsh, PC, Dunger, DB, Cole, TJ
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
A longitudinal analysis on the effect of hormone use on allostatic load in perimenopausal women
Aging and Health ResearchBackground: Allostatic load (AL), a measure of physiologic dysregulation across multiple systems, has been shown to increase as women age and go through menopause. While hormone use has been shown to help with the relief of menopausal symptoms, it is not
Pamela Lamisi Alebna +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Intein-mediated thyroid hormone biosensors: towards controlled delivery of hormone therapy
Frontiers in Systems BiologyAlthough blood sampling and medical imaging are well-established techniques in clinical diagnostics, they often require long post-processing procedures.
Quim Martí-Baena +14 more
doaj +1 more source