Results 91 to 100 of about 6,835,633 (348)
Association Between Hormone Therapy and Muscle Mass in Postmenopausal Women
JAMA Network Open, 2019 Key Points Question In postmenopausal women 50 years or older, is estrogen-based hormone therapy associated with reduced loss of lean body mass compared with no hormone therapy?
A. Javed +3 more
semanticscholar +1 more source
Acromegaly: pathogenesis & treatment [PDF]
, 2019 Acromegaly is a multi-system disorder whose etiology is most often traced back to a growth hormone-secreting pituitary adenoma (PA). Growth hormone (GH) secretion promotes insulin-like growth factor 1 (IGF-1) release from peripheral tissues, leading to ...
Tilvawala, Megha
core
Role for growth regulation by estrogen in breast cancer 1 (GREB1) in hormone-dependent cancers [PDF]
, 2018 Sex hormones play important roles in the onset and progression of several cancers, such as breast, ovarian, and prostate cancer. Although drugs targeting sex hormone function are useful in treating cancer, tumors often develop resistance.
Cheng, Meng +2 more
core +2 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Non-conventional hormone therapy - Tissue-specific Tibolone-Caution
Journal of Mid-Life Health, 2010 Objectives: The present retrospective study was undertaken to assess safety profile of long term Tibolone therapy when one of my patients developed carcinoma breast. Methods: Fifty patients who were put on Tibolone were studied as regards the indication
Jyotsna Potdar
doaj +1 more source
Influence of mirtazapine on salivary cortisol in depressed patients [PDF]
, 2003 Unlike other antidepressants, mirtazapine does not inhibit the reuptake of norepinephrine or serotonin but acts as an antagonist at presynaptic alpha(2)-receptors, at postsynaptic 5-HT2 and 5-HT3 receptors, and at histaminergic H1 receptors. Furthermore,
Baghai, Thomas C. +3 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Thyroid Hormone Therapy for Potential Heart Donors: A Comprehensive Review of Clinical Trials
BiomedicinesBackground: Due to neurohormonal disturbances that occur following brain death, thyroid hormone therapy has been proposed as a means to enhance cardiac function in brain-dead organ donors.
Mushood Ahmed +19 more
doaj +1 more source
A structural magnetic resonance imaging study in transgender persons on cross-sex hormone therapy [PDF]
, 2016 <b><i>Background:</i></b> To date, research findings are inconsistent about whether the neuroanatomy in transgender persons resembles that of their natal sex or their gender identity.
Landré, Lionel +3 more
core +2 more sources