Results 91 to 100 of about 474,365 (309)

Immunofunctional assay of human growth hormone (hGH) in serum: A possible consensus for quantitative hGH measurement [PDF]

, 1996
Confirmation of the diagnosis of GH deficiency in adults and children involves provocative testing for human (h) GH. Different commercially available immunoassays yield largely discrepant results in the measurement of GH levels in human serum.
Strasburger, Christian J., Pflaum, Claus-Dieter, Dressendörfer, Regina A., Wu, Zida   +3 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

NONALCOHOLIC FATTY LIVER DISEASE IN MENOPAUSAL WOMEN

Arquivos de Gastroenterologia, 2013
Context Nonalcoholic Fatty Liver Disease (NAFLD) is common in postmenopausal women. It is associated with metabolic syndrome. However, the influence of hormone replacement therapy in NAFLD development in these women needs to be investigated.
Gesira Soares de Assis FLORENTINO, Helma Pinchemel COTRIM, Consuelo Padilha VILAR, Andre Vinicius de Assis FLORENTINO, Geruza Maria Almeida GUIMARAES, Victorino Spinelli Toscano BARRETO   +5 more
doaj   +1 more source

External validation of anti-Müllerian hormone based prediction of live birth in assisted conception [PDF]

, 2013
<p>Background - Chronological age and oocyte yield are independent determinants of live birth in assisted conception. Anti-Müllerian hormone (AMH) is strongly associated with oocyte yield after controlled ovarian stimulation.
Grisendi, V., Lloyd, S.M., McConnachie, A., Fleming, R., Khader, A., La Marca, A., Nelson, S.M.   +6 more
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Celecoxib plus hormone therapy versus hormone therapy alone for hormone-sensitive prostate cancer: first results from the STAMPEDE multiarm, multistage, randomised controlled trial

, 2012
BACKGROUND:Long-term hormone therapy alone is standard care for metastatic or high-risk, non-metastatic prostate cancer. STAMPEDE--an international, open-label, randomised controlled trial--uses a novel multiarm, multistage design to assess whether the ...
Russell, J. Martin, Ritchie, A.W.S., Sydes, Matthew R., Russell, J Martin, O'Sullivan, JM, Mason, Malcolm D., Mason, MD, Dearnaley, DP, Birtle, Alison J, Thalmann, George N, Srihari, Narayanan, Protheroe, A, Parmar, Mahesh K. B., STAMPEDE Investigators, James, Nicholas D, Dearnaley, D.P., O'Sullivan, Joe M., Sanders, K, Bertelli, Gianfilippo, Mason, M.D., Birtle, A.J., Birtle, Alison J., Jovic, Gordana, Sanders, Karen, Russell, J.M., Dwyer, John, Russell, JM, Clarke, N.W., Parmar, M.K.B., Parmar, Mahesh KB, Sydes, MR, O'Sullivan, Joe M, Dwyer, J, Protheroe, A., Dwyer, J., Anderson, John, Parmar, Mahesh K B, Thalmann, GN, Birtle, AJ, Ritchie, AW, James, Nicholas D., Ritchie, Alastair W S, Clarke, NW, James, Nicholas, Parmar, MK, Anderson, J., Thalmann, G.N., Srihari, N., Srihari, N, Sydes, M.R., Clarke, Noel W, Ritchie, Alastair W. S., Clarke, Noel W., Jovic, G, Thalmann, George N., Protheroe, Andrew, Bertelli, G., Mason, Malcolm David, STAMPEDE investigators,, Bertelli, G, O'Sullivan, Joe; id_orcid, O'Sullivan, J.M., Ritchie, Alastair WS, Sanders, K., Dearnaley, David P., Sydes, Matthew R, Dearnaley, David P, James, N.D., Sheehan, Denise, Jovic, G., Mason, Malcolm D, Sheehan, D, Sheehan, D.   +72 more
core   +1 more source