Results 61 to 70 of about 5,954,376 (381)

The Clinical Significance of Subclinical Thyroid Dysfunction. [PDF]

, 2008
Subclinical thyroid disease (SCTD) is defined as serum free T(4) and free T(3) levels within their respective reference ranges in the presence of abnormal serum TSH levels.
BIONDI, BERNADETTE, COOPER DS
core   +1 more source

Cognition, Mood and Sleep in Menopausal Transition: The Role of Menopause Hormone Therapy

Medicina, 2019
During the menopausal transition, which begins four to six years before cessation of menses, middle-aged women experience a progressive change in ovarian activity and a physiologic deterioration of hypothalamic-pituitary-ovarian axis function associated ...
Giulia Gava, Isabella Orsili, Stefania Alvisi, I. Mancini, R. Seracchioli, M. Meriggiola   +5 more
semanticscholar   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Treatment of symptoms of the menopause: an endocrine society clinical practice guideline [PDF]

, 2015
Objective: The objective of this document is to generate a practice guideline for the management and treatment of symptoms of the menopause. Participants: The Treatment of Symptoms of the Menopause Task Force included six experts, a methodologist, and
Davis, Susan R., Gompel, Anne, Lumsden, Mary Ann, Murad, M. Hassan, Pinkerton, JoAnn V., Santen, Richard J., Stuenkel, Cynthia A.   +6 more
core   +1 more source

Gender-Affirming Hormone Therapy, Vascular Health and Cardiovascular Disease in Transgender Adults

HYPERTENSION, 2019
Gender-affirming or cross-sex hormone therapy is integral to the management of transgender individuals yet our appreciation of the effects of such hormones on cardiovascular health is limited.
Paul J. Connelly, E. Marie Freel, C. Perry, J. Ewan, R. Touyz, G. Currie, C. Delles   +6 more
semanticscholar   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Hormone replacement therapy perspectives

Frontiers in Global Women's Health
Hormone replacement therapy (HRT), also known as menopausal hormone therapy (MHT), was looked upon as a fountain of youth that kept women young and reduced cardiovascular disease. This led to a large-scale study called the Women's Health Initiative (WHI)
Dohn Kissinger
doaj   +1 more source

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

Molecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou   +11 more
wiley   +1 more source

Prevalence of menopausal symptoms and attitudes towards menopausal hormone therapy in women aged 40–60 years: a cross-sectional study

BMC Women's Health, 2023
Background Menopause is a specific physical and psychological transition period for women, during which they experience a series of menopausal symptoms. Menopausal hormone therapy is an important treatment for improving menopausal symptoms. Helping women
Jie Lu, Kangfen Li, Xinlie Zheng, Ran Liu, Min Chen, Jingyun Xian, Suhua Tu, Lingling Xie   +7 more
doaj   +1 more source

Phosphorylation of the androgen receptor is associated with reduced survival in hormonerefractory prostate cancer patients [PDF]

, 2008
Cell line studies demonstrate that the PI3K/Akt pathway is upregulated in hormone-refractory prostate cancer (HRPC) and can result in phosphorylation of the androgen receptor (AR).
C Le Page, D Ruggero, DA Altomare, G Ayala, GJ Bubley, H Murillo, HK Lin, HK Lin, J Edwards, J Edwards, J M S Bartlett, JA Fraser, JQ Cheng, KS McCarty Jr, L Cleeve, L K Gemmell, L Yang, M Manin, N Gao, N Pommery, P McCall, PK Majumder, PM Ghosh, R Mukherjee, SN Malik, T Kirkegaard, YD Liao   +26 more
core   +2 more sources