Results 221 to 230 of about 1,689,718 (296)

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Thyroid hormones, mitochondria, aging, and cancer. [PDF]

Front Endocrinol (Lausanne)
Glinsky G, Hercbergs A, Davis PJ.
europepmc   +1 more source

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Longitudinal trajectories of cognitive decline and temporal lobe atrophy based on baseline gonadotropins and testosterone. [PDF]

Front Neurosci
Zhao M, Jiang J, Wang L, Yang S, Li W, Ren Q, Zhang H, Jiang T, Jiang S, Zhou J, Xu J.   +10 more
europepmc   +1 more source

Sexual dimorphism in cancer: molecular mechanisms and precision oncology perspectives. [PDF]

Biol Sex Differ
Wang Z, Hu H, Bao Y, Ren G, Yang C.
europepmc   +1 more source

Thyroid hormones and breast cancer: untangling the association. [PDF]

EBioMedicine
Fernandes I, Cockburn JG, Narod SA, Jerzak KJ.   +3 more
europepmc   +1 more source

Mapping molluscan endocrinology: a systematic and critical appraisal. [PDF]

Biol Rev Camb Philos Soc
Panagiotidis K, Miller TH, Martin OV, Baynes A.   +3 more
europepmc   +1 more source

Sex hormone dysregulation after traumatic brain injury: interactions with sleep disturbances and seizure susceptibility. [PDF]

Front Neurosci
Elkinbard IS, Ritterbusch D, Shandra O, Rowe RK.   +3 more
europepmc   +1 more source