Results 121 to 130 of about 435,267 (291)

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Effect of Mercuric Chloride on Kinetic Properties of Horseradish Peroxidase [PDF]

Iranian Journal of Public Health, 2006
Mercury is one of the three major environmental metal poisons, and mercuric chloride is a highly reactive compound which can harm cells by a variety of mechanisms including direct interaction with sulphydryl groups of proteins and enzymes, therefore ...
N Einollahi, S Abbasi, N Dashti, F Vaezzadeh   +3 more
doaj  

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Uptake and axonal transport of horseradish peroxidase isoenzymes by different neuronal types

, 1987
The uptake and transport of basic and acidic horseradish peroxidase isoenzymes was compared in the neuromuscular, visual and olfatory systems of Xenopus larvae and postmetamorphic frogs.
Giorgi P.P., Key B.
core   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Efficacy of Horseradish Peroxidase (HRP) Enzyme Process and H2O2 in Removal of Linear Alkyl Benzene Sulfonate (LAS) from Aqueous Solution

Journal of Mazandaran University of Medical Sciences, 2018
Background and purpose: Enzymatic treatment, due to various benefits, has attracted many researchers since long time ago. Anionic detergents are one of the largest families of detergents that entered into the environment in recent decades.
Fathollah Gholami-Borujeni, Fatemeh Nejatzadeh, Mostafa Jamalan   +2 more
doaj  

Radical‐Mediated In Situ Fluorescence Dye Deposition: A Simple Interfacial Signal Amplification Reaction for Ultrasensitive Immunoassay on Barcode Beads

Advanced Science, EarlyView.
A radical‐mediated in situ fluorescence dye deposition (RIFD) reaction containing merely three elements of beads, dyes, and radicals is discovered for the first time, and its underlying mechanism is elucidated. This simple RIFD enables the interfacial and ultrafast deposition of free dyes onto barcode beads, serving as a powerful signal amplification ...
Jiayu Zhang, Yao Wang, Xinyi Huang, Haiyu Wu, Qiuning Lin, Hongchen Gu, Li Jiang, Linyong Zhu, Hong Xu   +8 more
wiley   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source