Results 41 to 50 of about 350,586 (260)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Comparison of two peroxidases with high potential for biotechnology applications – HRP vs. APEX2

Computational and Structural Biotechnology Journal
Peroxidases are essential elements in many biotechnological applications. An especially interesting concept involves split enzymes, where the enzyme is separated into two smaller and inactive proteins that can dimerize into a fully active enzyme.
Sanja Škulj, Matej Kožić, Antun Barišić, Aitor Vega, Xevi Biarnés, Ivo Piantanida, Ivan Barisic, Branimir Bertoša   +7 more
doaj   +1 more source

Oxidation of NAD dimers by horseradish peroxidase [PDF]

Biochemical Journal, 1985
Horseradish peroxidase catalyses the oxidation of NAD dimers, (NAD)2, to NAD+ in accordance with a reaction that is pH-dependent and requires 1 mol of O2 per 2 mol of (NAD)2. Horseradish peroxidase also catalyses the peroxidation of (NAD)2 to NAD+. In contrast, bacterial NADH peroxidase does not catalyse the peroxidation or the oxidation of (NAD)2.
AVIGLIANO L., CARELLI V., CASINI, Antonio, FINAZZI AGRÒ A., LIBERATORE F.   +4 more
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

WEAK-ASSOCIATED WITH CELL WALL PEROXIDASE DURING THE ROOT INFECTION [PDF]

Journal of Stress Physiology & Biochemistry, 2008
The role of weak-associated potato cell wall peroxidase in potato resistance to ring rot pathogen is shown. The data obtained showed that an addition of anti-horseradish peroxidase antibodies to resistant to this pathogen potato cv Lugovskoy cell culture
Graskova I.A., Epova K.Y., Kusnetsova E.V., Kolesnichenko A.V., Voinikov V.K.   +4 more
doaj  

Effect of lyophilization on HRP–antibody conjugation: an enhanced antibody labeling technology

BMC Research Notes, 2018
Objective Immunoassay usually deal with the antibody labeling with various reporter molecules, one such useful reporter molecule is horseradish peroxidase (HRPO).
Saikant Regidi, Shilpa Ravindran, Ashitha L. Vijayan, Vani Maya, Lakshmi Sreedharan, Jeslin Varghese, Kartik Ramaswami, Manoj Gopi   +7 more
doaj   +1 more source

NewN-Glycans in Horseradish Peroxidase

Analytical Biochemistry, 1998
We describe here the structures of several new N-glycan oligosaccharides from horseradish peroxidase (HRP). Glycopeptides from HRP were digested with glycoamidase A (from sweet almond) to release the N-glycans. The oligosaccharides were reductively aminated with 2-aminopyridine, and separated by high-performance liquid chromatography on octadecylsilyl-
N, Takahashi, K B, Lee, H, Nakagawa, Y, Tsukamoto, K, Masuda, Y C, Lee   +5 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Immobilization of peroxidase from fresh horseradish extract for anthraquinone dye decolorization

Zaštita Materijala, 2015
Synthetic dyes are used in all sectors of industry and represent a serious ecological problem. By the presence, anthraquinone dyes are right after the azo dyes.
Nataša Ž. Šekuljica, Nevena Ž. Prlainović, Nevena M. Lukić, Aleksandra M. Jakovljević, Sanja Ž. Grbavčić, Dušan Ž. Mijin, Jugović Zorica D. Knežević   +6 more
doaj   +1 more source