Results 51 to 60 of about 435,267 (291)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The diameters of guinea pig auditory nerve fibres: Distribution and correlation with spontaneous rate [PDF]

, 1993
In the mammalian auditory nerve physiological recordings revealed that the spontaneous discharge rate of single auditory fibres correlates with the diversity of input-output functions which may be important for intensity discrimination (e.g., Sachs and ...
Wilson, Shirley, Otto Gleich, Gleich, Otto, Shirley Wilson   +3 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Immobilization of peroxidase from fresh horseradish extract for anthraquinone dye decolorization

Zaštita Materijala, 2015
Synthetic dyes are used in all sectors of industry and represent a serious ecological problem. By the presence, anthraquinone dyes are right after the azo dyes.
Nataša Ž. Šekuljica, Nevena Ž. Prlainović, Nevena M. Lukić, Aleksandra M. Jakovljević, Sanja Ž. Grbavčić, Dušan Ž. Mijin, Jugović Zorica D. Knežević   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Degradação de corantes e efluentes têxteis pela enzima Horseradish peroxidase (HRP) [PDF]

, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia QuímicaEste trabalho apresenta uma avaliação do potencial da enzima vegetal Horseradish peroxidase (HRP), para a descoloração de ...
Forgiarini, Eliane
core  

Comparison of two peroxidases with high potential for biotechnology applications – HRP vs. APEX2

Computational and Structural Biotechnology Journal
Peroxidases are essential elements in many biotechnological applications. An especially interesting concept involves split enzymes, where the enzyme is separated into two smaller and inactive proteins that can dimerize into a fully active enzyme.
Sanja Škulj, Matej Kožić, Antun Barišić, Aitor Vega, Xevi Biarnés, Ivo Piantanida, Ivan Barisic, Branimir Bertoša   +7 more
doaj   +1 more source

Immobilization of periodate-oxidized horseradish peroxidase by adsorption on sepiolite [PDF]

Journal of the Serbian Chemical Society
Horseradish peroxidases (HRP), native and periodate-oxidized were immobilized onto sepiolite clay mineral by adsorption. Both peroxidases were adsorbed on this carrier in different quantities.
Surudžić Nevena, Simić Miloš, Crnoglavac-Popović Milica, El Gahwash Reyadh, Spasojević-Savković Milica, Prodanović Radivoje, Prodanović Olivera   +6 more
doaj   +1 more source

NewN-Glycans in Horseradish Peroxidase

Analytical Biochemistry, 1998
We describe here the structures of several new N-glycan oligosaccharides from horseradish peroxidase (HRP). Glycopeptides from HRP were digested with glycoamidase A (from sweet almond) to release the N-glycans. The oligosaccharides were reductively aminated with 2-aminopyridine, and separated by high-performance liquid chromatography on octadecylsilyl-
N, Takahashi, K B, Lee, H, Nakagawa, Y, Tsukamoto, K, Masuda, Y C, Lee   +5 more
openaire   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source