Results 61 to 70 of about 832,650 (351)

Runs of homozygosity reveal signatures of positive selection for reproduction traits in breed and non-breed horses

BMC Genomics, 2015
Modern horses represent heterogeneous populations specifically selected for appearance and performance. Genomic regions under high selective pressure show characteristic runs of homozygosity (ROH) which represent a low genetic diversity.
J. Metzger, M. Karwath, R. Tonda, S. Beltran, L. Agueda, M. Gut, I. Gut, O. Distl   +7 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Trigeminal Nerve Asymmetry in Horses With Idiopathic Trigeminal‐Mediated Headshaking: A Retrospective Case‐Control Magnetic Resonance Imaging Study

Journal of Veterinary Internal Medicine
Background Nerve atrophy results in trigeminal nerve (TN) asymmetry detectable by magnetic resonance imaging (MRI) in humans, but similar studies have not been performed in horses with idiopathic trigeminal‐mediated headshaking (ITMHS). Hypothesis Horses
Frederik Heun, Julien Delarocque, Karsten Feige, Maren Hellige   +3 more
doaj   +1 more source

Anaesthetic Management of a 1-Month-Old Puppy Undergoing Lateral Thoracotomy for Vascular Ring Anomaly Correction

Case Reports in Veterinary Medicine, 2011
A 1-month-old male flat-coated retriever was anaesthetized for correction of oesophageal constriction caused by a vascular ring anomaly. Anaesthesia was uneventfully induced with intravenous fentanyl, diazepam, and propofol and maintained with isoflurane
Olga Martin Jurado, Martina Mosing, Regula Bettschart-Wolfensberger   +2 more
doaj   +1 more source

Nasal and tracheobronchial nitric oxide production and its influence on oxygenation in horses undergoing total intravenous anaesthesia

BMC Veterinary Research, 2022
Background The present study aimed to investigate the effect of endotracheal intubation on nasal and tracheal endogenous NO concentrations, gas exchange and oxygenation in horses undergoing general anaesthesia.
Henriette L. Wilkens, Stephan Neudeck, Sabine B. R. Kästner   +2 more
doaj   +1 more source

Impact of Different Diagnostic Procedures on Diagnosis, Therapy, and Outcome in Horses with Headshaking: Recommendations for Fast-Track Advanced Diagnostic and Therapeutic Protocols

Animals, 2022
Most horses affected by headshaking (HS) are diagnosed with idiopathic trigeminal-mediated headshaking (i-TMHS) when no underlying disease is found. Diagnosis is made by the exclusion of differentials considering history, clinical signs, and diagnostic ...
Tanja Kloock, Maren Hellige, Anke Kloock, Karsten Feige, Tobias Niebuhr   +4 more
doaj   +1 more source

Faecal microbiota characterisation of horses using 16 rdna barcoded pyrosequencing, and carriage rate of clostridium difficile at hospital admission

BMC Microbiology, 2015
The equine faecal microbiota is very complex and remains largely unknown, while interspecies interactions have an important contribution to animal health. Clostridium difficile has been identified as an important cause of diarrhoea in horses.
C. Rodriguez, B. Taminiau, B. Brévers, V. Avesani, J. van Broeck, A. Leroux, Marjorie Gallot, Antoine Bruwier, H. Amory, M. Delmée, G. Daube   +10 more
semanticscholar   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Hypoxic training increases maximal oxygen consumption in Thoroughbred horses well-trained in normoxia. [PDF]

, 2017
Hypoxic training is effective for improving athletic performance in humans. It increases maximal oxygen consumption (V̇O2max) more than normoxic training in untrained horses. However, the effects of hypoxic training on well-trained horses are unclear. We
Jones, James H, Mukai, Kazutaka, Ohmura, Hajime, Takahashi, Toshiyuki, Takahashi, Yuji   +4 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source