Results 51 to 60 of about 572,754 (324)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Optimal Number of Hospital Beds Under Uncertainty: A Costs Management Approach [PDF]

Journal of Optimization in Industrial Engineering, 2018
Equipping hospital beds uses a great deal of a hospital''''s resources. Therefore, it is essential to consider the hospital beds'''' efficiency. To increase its efficiency, a fuzzy unrestricted model for managing hospital expenses is presented in this ...
Saeed Khalili, Mohammad Ghodoosi, Javad Hasanpour   +2 more
doaj   +1 more source

Navigating hospitals safely through the COVID-19 epidemic tide: Predicting case load for adjusting bed capacity

Infection control and hospital epidemiology, 2020
Background: The pressures exerted by the coronavirus disease 2019 (COVID-19) pandemic pose an unprecedented demand on healthcare services. Hospitals become rapidly overwhelmed when patients requiring life-saving support outpace available capacities ...
T. Donker, Fabian Bürkin, M. Wolkewitz, Christian Haverkamp, Dominic Christoffel, Oliver Kappert, T. Hammer, Hans-Jörg Busch, P. Biever, J. Kalbhenn, H. Bürkle, W. Kern, Frederik Wenz, H. Grundmann   +13 more
semanticscholar   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Feasibility of forecasting future critical care bed availability using bed management data

BMJ Health & Care Informatics
Objectives This project aims to determine the feasibility of predicting future critical care bed availability using data-driven computational forecast modelling and routinely collected hospital bed management data.Methods In this proof-of-concept, single-
Laura Moss, John Palmer, Aileen Neilson, Areti Manataki, Tsz-Yan Milly Lo   +4 more
doaj   +1 more source

Location‐Specific Hematoma Volume Predicts Early Neurological Deterioration in Supratentorial ICH

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early neurological deterioration (END) adversely affects outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to determine the location‐specific hematoma volumes for END in supratentorial ICH patients. Methods We retrospectively analyzed supratentorial ICH patients presenting from two prospective cohorts.
Zuoqiao Li, Guilin Meng, Zijie Wang, Xiao Hu, Jing Cheng, Chu Chen, Tiannan Yang, Jiaxin Luo, Zizhen Meng, Xueyun Liu, Qi Li   +10 more
wiley   +1 more source

Unit managers between fluctuating demand and fixed staffing: a quantitative study in psychiatric nursing

Frontiers in Health Services
Balancing patient demand with nurse staffing remains a central challenge in inpatient care. In psychiatric settings, patient-side fluctuations create variability that is difficult to reconcile with fixed rosters and limited staffing flexibility.
Michael Ketzer, Michael Ketzer, Beatrice Gehri, Beatrice Gehri, André Nienaber, André Nienaber, Christian G. Huber, Michael Simon   +7 more
doaj   +1 more source

Kanban as a strategy for hospital bed management: analysis of strengths, weaknesses, opportunities, and threats [PDF]

Revista Gaúcha de Enfermagem
Objective: To analyze the strengths, weaknesses, opportunities, and threats in using the Kanban method for hospital bed management. Method: This qualitative descriptive study was conducted with 23 healthcare professionals from a university hospital ...
Nara Beatriz Silveira, Rosemary Silva da Silveira, Jamila Geri Tomaschewski Barlem, Simoní Saraiva Bordignon, Emili dos Santos Leão   +4 more
doaj   +1 more source

Balancing revenue generation with capacity generation: case distribution, financial impact and hospital capacity changes from cancelling or resuming elective surgeries in the US during COVID-19

BMC Health Services Research, 2020
Background To increase bed capacity and resources, hospitals have postponed elective surgeries, although the financial impact of this decision is unknown.
Joseph E. Tonna, Heidi A. Hanson, Jessica N. Cohan, Marta L. McCrum, Joshua J. Horns, Benjamin S. Brooke, Rupam Das, Brenna C. Kelly, Alexander John Campbell, James Hotaling   +9 more
doaj   +1 more source

Coacervates Made of Elastin‐Like Polypeptides Fused with Melanocyte‐Stimulating Hormone and Monocyte Chemoattractant Protein Enhance Skin Wound Healing in Spinal Cord‐Injured Mice

Advanced Healthcare Materials, EarlyView.
Pressure skin wounds are frequent complications after spinal cord injury (SCI), with impaired healing due to vascular and immune deficits. Elastin‐like polypeptides (ELP) fused to α‐MSH (MSH‐ELP) or MCP‐1 (MCP‐ELP) are developed and tested on these wounds. The resulting nanoparticles are non‐toxic and bioactive, and they enhance macrophage recruitment,
Suneel Kumar, Dhruv Patel, Greeshma Manjunath, Shashank Madhavan, Ashley Mathew, Dnyaneshwari Rananavare, Jahnavi Shah, Francois Berthiaume   +7 more
wiley   +1 more source