Results 51 to 60 of about 1,609,172 (298)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Evaluating the Waste Prevention Potential of a Multi- versus Single-Use Surgical Stapler

open access: yesRisk Management and Healthcare Policy, 2021
Markus Meissner,1 Sabrina Lichtnegger,1 Scott Gibson,2 Rhodri Saunders2 1Austrian Institute of Ecology, Vienna, Austria; 2Coreva Scientific GmbH & Co KG, Koenigswinter, GermanyCorrespondence: Rhodri SaundersCoreva Scientific GmbH & Co KG, Koenigswinter ...
Meissner M   +3 more
doaj  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

An Exploratory Analysis of the Association Between Hospital Labor Costs and the Quality of Care

open access: yesRisk Management and Healthcare Policy, 2023
Brad Beauvais,1 Clemens Scott Kruse,1 Zo Ramamonjiarivelo,1 Rohit Pradhan,1 Keya Sen,1 Lawrence Fulton2 1School of Health Administration, Texas State University, San Marcos, TX, USA; 2Woods College of Advancing Studies, Boston College, Chestnut Hill, MA,
Beauvais B   +5 more
doaj  

Aiming Higher: Results From a State Scorecard on Health System Performance [PDF]

open access: yes, 2007
Assesses state variation across key dimensions of health system performance -- access, quality, avoidable hospital use and costs, equity, and healthy lives -- and assigns overall state rankings as well as ranks on each ...
Cathy Schoen   +4 more
core  

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

Investigation of the Effect of Aging on Health Costs: A Systematic Review

open access: yesپژوهش‌های سلامت‌محور, 2020
Investigation of the Effect of Aging on Health Costs: A Systematic Review   Rezapour Aziz1, Arabloo Jalal2, Alipour Vahid3*, Alipour Samira4   1. Associate Professor, Health Management and Economics Research Center, Iran University of Medical Sciences ...
Aziz Rezapour   +3 more
doaj  

Hospital and Physician Capacity Update [PDF]

open access: yes, 2009
Offers an alternative view of healthcare costs by examining trends in hospital capacity and healthcare labor across regions. Outlines how effective management of healthcare capacity would enable affordable quality care that meets patient needs and ...
David C. Goodman   +2 more
core  

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