Results 191 to 200 of about 460,810 (250)

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Next-generation sequencing elucidates the distinct mutational landscape of SMARCA4-deficient lung cancer. [PDF]

Oncol Lett
Yang F, Yang Y, Chen Z, Li Y, Song Y.
europepmc   +1 more source

Engineered Carbon Dots from a Traditional Herb Pair Orchestrate Concurrent Antioxidant and AP‐1‐Mediated Inflammation to Attenuate Renal Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study integrates two complementary traditional Chinese medicine components as precursors to synthesize bioactive AM‐AS@CDs. Compared with single‐component CDs, these dual‐component CDs exhibit enhanced antioxidant capacity and superior renoprotective effects.
Bixiao Liu, Fuying Zhu, Zhuqing Wang, Jiawen Chen, Xiaomiao Cui, Congzhong Yang, Yao Peng, Dengyuan Feng, Li Lu, Hui Wei, Xiaozhi Zhao   +10 more
wiley   +1 more source

Construction and initial validation of key gene network for progesterone resistance in endometrial cancer based on genome-wide CRISPR screening. [PDF]

Sci Rep
Li X, Wang S, Qiu Z, Sun R, Wang T, Ren X, Lv B, Ma X, Cheng L, Liu Y, Jiang J.   +10 more
europepmc   +1 more source

Taking it a step farther: acknowledging librarians' systematic review work in the promotion or tenure process. [PDF]

J Med Libr Assoc
Raszewski R, Goben A.
europepmc   +1 more source

Corrigenda: Pain, Agitation, Delirium, and Iatrogenic Withdrawal Syndrome Management in Children Who Are Critically Ill: Protocol for a European Clinical Practice Guideline Using the Grading of Recommendations Assessment, Development, and Evaluation Approach. [PDF]

JMIR Res Protoc
MacDonald I, Cavin-Trombert A, Jaques C, De Clifford-Faugère G, De Cock PA, de Wildt SN, Dmytriiev D, Engel J, Fazio PC, George S, Goyer I, Harðardóttir A, Harris J, Horváth K, Ista E, Mencía S, Metsvaht T, Mondardini MC, Oualha M, Perez MH, Pietrzkiewicz K, Sperotto F, Wyness B, Yalındağ N, ESPNIC Nursing and Allied Healthcare Professionals Section, ESPNIC Pharmacology Section, Amigoni A, Ramelet AS.   +27 more
europepmc   +1 more source

Designing a rheumatology and immunology nursing training model for resource-limited settings: application of the Medical Research Council framework. [PDF]

Front Med (Lausanne)
Xia L, Feng F, Ma Y, Yan B, Yang M, Yang J, Chi S, Fang L, Li J, Huang D, Lou C, Xia Z, Mei J, Mai L, Xia Y, Hayashi N.   +15 more
europepmc   +1 more source

Uncovering functional variants using a high-efficiency PE3-based screening platform. [PDF]

Sci Adv
Huang S, Tao W, Li X, Guo J, Zhang Y, Li G, Zhang P, Zhang G, Li G, Fan G, Zhang SM, Huang X.   +11 more
europepmc   +1 more source