Results 81 to 90 of about 1,758,521 (311)

Three-year follow-up mortality rate in Malta [PDF]

, 2016
Introduction: Primary osteoporosis is a major factor in fragility hip fractures. The index fracture is loaded with morbidity and increased mortality in these very fragile patients. The aim of the study was to evaluate the mortality rate after 3 months, 1
Grech, Stephan, Cuschieri, Sarah
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Fine particle components and health--a systematic review and meta-analysis of epidemiological time series studies of daily mortality and hospital admissions.

, 2015
Short-term exposure to fine particle mass (PM) has been associated with adverse health effects, but little is known about the relative toxicity of particle components.
H Ross Anderson, Inga C Mills, Heather A Walton, Anderson, HR, Anderson, Ross, Mills, IC, Richard W Atkinson, Atkinson, RW, Mills, Inga, Walton, Heather, Walton, HA, Atkinson, Richard   +11 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Efficacy of quick Sequential Organ Failure Assessment with lactate concentration for predicting mortality in patients with community-acquired pneumonia in the emergency department [PDF]

Clinical and Experimental Emergency Medicine, 2019
Objective Community-acquired pneumonia (CAP) is a major cause of sepsis, and sepsis-related acute organ dysfunction affects patient mortality. Although the quick Sequential Organ Failure Assessment (qSOFA) is a new screening tool for patients with ...
Hwan Song, Hyung Gi Moon, Soo Hyun Kim
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Development and validation of a prediction model of hospital mortality for patients with cardiac arrest survived 24 hours after cardiopulmonary resuscitation

Frontiers in Cardiovascular Medicine
ObjectiveResearch on predictive models for hospital mortality in patients who have survived 24 h following cardiopulmonary resuscitation (CPR) is limited.
Renwei Zhang, Zhenxing Liu, Yumin Liu, Li Peng   +3 more
doaj   +1 more source

Validation of quick sequential organ failure assessment score for poor outcome prediction among emergency department patients with suspected infection [PDF]

Clinical and Experimental Emergency Medicine, 2019
Objective The quick sequential organ failure assessment (qSOFA) score, which includes mentation, systolic blood pressure, and respiratory rate, was developed to identify serious sepsis in out-of-hospital or emergency department (ED) settings.
Young Wha Sohn, Hye Young Jang, Suyeon Park, Youngjoo Lee, Young Shin Cho, Junbum Park, Heajin Chung, Sang-Il Kim   +7 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Is the maturity of hospitals' quality improvement systems associated with measures of quality and patient safety? [PDF]

, 2011
UNLABELLED: ABSTRACT: BACKGROUND: Previous research addressed the development of a classification scheme for quality improvement systems in European hospitals.
Saez, Mercedes, Andrew Thompson, Mercè Casas, Thompson, A, Casas Galofré, Mercè, Suñol, Rosa, Groene Oliver, Casas Mercè, Mora, N, Suñol, R, Thompson, Andrew, Saez Mercedes, Mora, Nuria, Mercedes Saez, Saez, M, Suñol Rosa, Casas, M, Nuria Mora, Groene, O, Thompson Andrew, Rosa Suñol, Mora Nuria, Oliver Groene, Casas, Mercè, Groene, Oliver, Suñol Sala, Rosa   +25 more
core   +1 more source