Results 51 to 60 of about 1,685,245 (302)

Wanted: Moral Courage in Canadian Child Welfare

, 2011
Child welfare stifles change and innovation in a system that desperately needs it by promoting conformity and awarding subordination to bad ideas (Blackstock, 2009).
Blackstock, Cindy
core   +1 more source

The responsibility of clinical pharmacists for the safety of medication use in hospitalized children: A Middle Eastern experience

Journal of Research in Pharmacy Practice, 2019
Objective: We aimed to detect and report the frequency of occurrence of drug-related problems (DRPs) in a Middle Eastern University Children's Hospital (Isfahan, Iran) and classify them in terms of their nature and cause to clarify the responsibility of ...
Khatereh Jafarian, Zahra Allameh, Mehrdad Memarzadeh, Ali Saffaei, Payam Peymani, Ali Mohammad Sabzghabaee   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

O EFEITO DA UTILIZAÇÃO DO BRINQUEDO TERAPÊUTICO, PELA ENFERMEIRA PEDIATRA, SOBRE O COMPORTAMENTO DE CRIANÇAS RECÉM-HOSPITALIZADAS

Revista da Escola de Enfermagem da USP
O trabalho descreve a realização e os resultados de uma pesquisa experimental, executada entre crianças de 3 a 5 anos, recém-hospitalizadas, com utilização da técnica de brinquedo terapêutico.
Circéa Amalia Ribeiro
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Rekindling the Sacred Fire for Children and Families

, 2019
This video describes the partnership between the Sun Lodge Village and Peguis Child and Family Services in Peguis First Nation, Manitoba. Together we are providing opportunities for families, youth, and children to find their way back to traditional ...
Peguis Child and Family Services, Sun Lodge Village, Peguis Child and Family Services, Organization:, Sun Lodge Village, Organization:   +3 more
core   +1 more source

Evolução do estado nutricional de crianças submetidas à internação hospitalar Evolution of nutritional status in hospitalized children

Jornal de Pediatria, 2002
Objetivos: analisar a evolução do estado nutricional de crianças internadas no Hospital Universitário da UFAL. Metodologia: estudo retrospectivo de 52 crianças (0 a 10 anos), que estiveram internadas no Hospital Universitário por mais de 10 dias ...
Haroldo S. Ferreira, Adijane O.S. França   +1 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Here be dragons! Reconciling Indigenous and Western knowledge to improve Aboriginal child welfare

, 2007
The authors discuss the factors regarding the reconciliation movement in reconciling Indigenous and Western Knowledge to improve child welfare practice with respect to Aboriginal peoples.
Bastien, Betty, LaFrance, Jean
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source