Results 81 to 90 of about 18,891 (267)

Clinical Characteristics and Progression of Pachychoroid and Conventional Geographic Atrophy

Ophthalmology Science
Purpose: To elucidate the clinical characteristics and progression rates of pachychoroid and conventional geographic atrophy (GA). Design: Retrospective, multicenter, observational study.
Yukiko Sato, MD, Naoko Ueda-Arakawa, MD, PhD, Ayako Takahashi, MD, PhD, Masahiro Miyake, MD, PhD, Yuki Mori, MD, PhD, Yasunori Miyara, MD, Chikako Hara, MD, PhD, Yoko Kitajima, MD, Ruka Maruko, MD, PhD, Moeko Kawai, MD, Hajime Takahashi, MD, PhD, Hideki Koizumi, MD, PhD, Maiko Maruyama-Inoue, MD, PhD, Yasuo Yanagi, MD, PhD, Tomohiro Iida, MD, PhD, Kanji Takahashi, MD, PhD, Taiji Sakamoto, MD, PhD, Akitaka Tsujikawa, MD, PhD   +17 more
doaj   +1 more source

Development and Analytical Validation of a Laboratory‐Customized TaqMan‐MGB Probe Method for CYP2C19 Genotyping

Journal of Clinical Laboratory Analysis, EarlyView.
A laboratory‐customized, open‐sequence TaqMan‐MGB probe assay was developed for detecting CYP2C19*2 and CYP2C19*17 polymorphisms using dried blood spot‐derived DNA. The assay demonstrated allele‐specific discrimination, candidate LODs of 1.17 × 102 copies/μL for CYP2C19*2 and 0.94 × 103 copies/μL for CYP2C19*17, and repeatability with CVs below 10%. In
Yaqun Liu, Lianghui Chen, Xuanyi Zheng, Peikui Yang, Yicun Chen, Chengsong Xie, Zhenxia Zhang, Yuzhong Zheng   +7 more
wiley   +1 more source

DNA Extracted From Aged Formalin‐Fixed Paraffin‐Embedded Specimens of Patients With Papillary Thyroid Carcinomas Can Be Used for Whole Exome Sequencing

Journal of Clinical Laboratory Analysis, EarlyView.
We aimed to assess the quality of DNA extracted from long‐term stored FFPE specimens of patients with papillary thyroid carcinoma from three hospitals in Hiroshima and their applicability to whole exome sequencing. FFPE samples preserved for up to 55 years may be amenable to sequencing with increased read depth.
Kousuke Tanimoto, Tomonori Hayashi, Hidewaki Nakagawa, Kazuhiro Maejima, Koji Arihiro, Megumu Fujihara, Takashi Nishisaka, Masahiro Ito, Masahiro Nakashima, Naohiro Kato, Zhenqiu Liu, Misa Imaizumi, Alina Brenner, Stephen J. Chanock, Osamu Tanabe, Kotaro Ozasa   +15 more
wiley   +1 more source

A Practical and Efficient Multiplex qPCR Assay for Simultaneous Detection of HLA Cross‐Reactive Groups and Human Platelet Antigens

Journal of Clinical Laboratory Analysis, EarlyView.
This assay enables multiplex genotyping of HLA‐CREGs and HPA alleles from whole blood using qPCR with an integrated parallel negative control. Results are interpreted based on amplification curves and Ct values, with validity dependent on strict quality control criteria for both the target reactions and the negative control.
Huimin Ji, Kaihao Feng, Yunping Xu, Le Chang, Ying Yan, Jie Ma, Yi Liu, Jinfeng Zeng, Huizhen Sun, Lunan Wang   +9 more
wiley   +1 more source

Image Quality of 1.5 T MRI Using Dual‐Type Deep Learning Reconstruction for Pancreatic Cystic Lesions: An Exploratory Comparison With Conventional 3 T MRI Without Deep Learning Reconstruction

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Dual‐type deep learning reconstruction (DLR) may improve the pancreatic MRI image quality; however, the effects of different DLR strengths at 1.5 T compared with the conventional 1.5 T and 3 T MRI without DLR remain unclear. Purpose To evaluate the image quality of 1.5 T MRI reconstructed with different DLR strengths for pancreatic ...
Masaki Tsuda, Taiki Nozaki, Koji Sumi, Minobu Kamo, Ippei Ozaki, Fumio Morimura, Eugene Nishi, Yohsuke Suyama, Hiroaki Sugiura, Hiromi Edo   +9 more
wiley   +1 more source

Deep Learning–Based Prediction of Glaucoma Severity and Progression Using Imo/TEMPO Screening Program

Ophthalmology Science
Purpose: To develop DeepISP, a deep learning model that predicts the comprehensive visual field (VF) information of the Humphrey visual field analyzer (HFA) based on rapid screening perimetry (Imo/TEMPO screening program [ISP]).
Kei Sano, MD, PhD, Euido Nishijima, MD, PhD, Shunsuke Sumi, MD, PhD, Takahiko Noro, MD, PhD, Shumpei Ogawa, MD, PhD, Yuka Igari, MD, Aiko Iwase, MD, PhD, Tadashi Nakano, MD, PhD   +7 more
doaj   +1 more source

The Double Pivot: A Mixed‐Methods Case Study of the NSF I‐Corps Customer Discovery Process in a University‐Spun Health AI Venture

Strategic Change, EarlyView.
ABSTRACT Deep‐technology ventures, particularly in medical artificial intelligence (AI), face a persistent “valley of death” where promising innovations fail to find viable business models despite technical merit. While the NSF I‐Corps program addresses this through structured customer discovery, little empirical research validates how specific market ...
Amil Khanzada, Takuji Takemoto
wiley   +1 more source

Baseline Relationships between Visual Function and Inflammatory Markers in the Registry of Moderated-Stage Retinitis Pigmentosa

Ophthalmology Science
Purpose: To analyze the association between visual function and inflammatory markers in the baseline data of a prospective natural history registry of patients with typical retinitis pigmentosa (RP) (Retinitis Pigmentosa Progression and Inflammatory ...
Takahiro Hisai, MD, Sakurako Shimokawa, MD, Masatoshi Fukushima, MD, PhD, Kohta Fujiwara, MD, PhD, Yoshito Koyanagi, MD, PhD, Akie Hirata, MD, PhD, Atsushi Takada, PharmD, Fuyuka Miyahara, Naoki Nakashima, MD, PhD, Yuko Kobayakawa, MD, PhD, Go Mawatari, CO, PhD, Masataka Ishizu, MD, PhD, Naoki Toyama, MD, Tomoko Kaida, MD, PhD, Kazunori Miyata, MD, PhD, Yasuhiro Ikeda, MD, PhD, Koh-Hei Sonoda, MD, PhD, Yusuke Murakami, MD, PhD   +17 more
doaj   +1 more source

Feasibility and Reproducibility of a Structure‐Guided Deep Learning Model for Automatic Detection of the Standard Sagittal Plane in First‐Trimester Nuchal Translucency Assessment Using 3D Ultrasound

Journal of Ultrasound in Medicine, EarlyView.
Objectives Accurate nuchal translucency (NT) measurement for assessing the risk of fetal genetic abnormalities requires precise acquisition of the mid‐sagittal plane (MSP). However, achieving an appropriate MSP is technically challenging due to anatomical variability and operator dependence inherent in conventional 2‐dimensional (2D) ultrasound.
Hayan Kwon, Hyewon Hur, Hyun Cheol Cho, Yun ji Jung, Suhra Kim, Ja‐Young Kwon   +5 more
wiley   +1 more source

Startups Driving Artificial Intelligence Into Clinical Dermatology

JEADV Clinical Practice, EarlyView.
ABSTRACT Artificial intelligence (AI) is rapidly transitioning from innovation to routine clinical application in dermatology. This review examines how AI‐enabled technologies are being developed and integrated across diverse clinical purposes and workflows.
Dominique Du Crest, Benjamin Miguel Monteagudo, Stanislas Vandier, Mullarkey Dan, Svedenhag Per, Jon Friis, Monisha Madhumita, Lilit Garibyan, Tu‐Anh Duong, Merete Haedersdal, Vinzent Kevin Ortner   +10 more
wiley   +1 more source