Results 111 to 120 of about 4,014,458 (336)

How accurately can supervised machine learning model predict a targeted psychiatric disorder?

BMC Psychiatry
Background Hoarding disorder (HD) is characterized by a compulsion to collect belongings, and to experience significant distress when parting from them. HD is often misdiagnosed for several reasons.
Haitham Jahrami, Amir H. Pakpour, Waqar Husain, Achraf Ammar, Zahra Saif, Ali Husain Alsalman, Adel Aloffi, Khaled Trabelsi, Seithikurippu R. Pandi-Perumal, Michael V. Vitiello   +9 more
doaj   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

Advanced Science, EarlyView.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng, Wenming Li, Tianhao Wang, Gaoran Ge, Wei Zhang, Yi Qin, Wenhao Li, Zebin Wu, Zhen Wang, Gang Rui, Yaozeng Xu, Dechun Geng   +11 more
wiley   +1 more source

Counterbalancing O‐GlcNAcylation and STAT3 Phosphorylation in Ventral Tegmental Area Dopaminergic Neurons Mediates Behavioral Adaptations to Acute Restraint Stress

Advanced Science, EarlyView.
Acute restraint stress enhances STAT3Ser727 phosphorylation in dopaminergic neurons in mice. This modification promotes the upregulation of GABBR2 and GABRB3, reduces neuronal activity, and contributes to anxiety‐like behavior and diminished reward‐seeking following stress exposure.
Mingshuo Shao, Yi Wu, Haiyang Wang, Chenchun Zhang, Ying Zhu, Yan Jiang, Changyou Jiang, Qiumin Le, Xing Liu, Lan Ma, Feifei Wang   +10 more
wiley   +1 more source

Fully Automated Deep Learning Enabled Miniature Mass Spectrometry System for Psychoactive Therapeutic Drug Monitoring

Advanced Science, EarlyView.
This study presents a fully automated miniature mass spectrometry system for high‐throughput therapeutic drug monitoring. Integrating magnetic solid‐phase extraction, self‐aspiration sampling miniature mass spectrometer, and U‐net deep learning quantitative algorithm, it achieves rapid (8 samples/30 min), precise (R2 > 0.99, RSD < 10%), and portable ...
Yuanhao Zhou, Jiawen Ai, Zi Ye, Kexin Chen, JingXiong Lin, Zhenhua Zhang, Mi Luo, Benjie Zhou, Shijian Xiang, Jianhua Zhou, Xinming Huo   +10 more
wiley   +1 more source

Hospital beds for psychiatric patients [PDF]

Bulletin of the Royal College of Psychiatrists, 1986
Members write to the College asking for guidance on planning services for psychiatric patients, and in particular on the desirable level of provision of hospital beds. At the request of the Executive and Finance Committee I am publishing the following information, based on a letter that I wrote to Regional Advisers.
openaire   +4 more sources

Oxytocin Reduces Subjective Fear in Naturalistic Social Contexts via Enhancing Top‐Down Middle Cingulate Amygdala Regulation and Brain‐Wide Fear Representations

Advanced Science, EarlyView.
This double‐blind, placebo‐controlled study demonstrates that intranasal oxytocin reduces subjective fear in immersive, naturalistic social (but not non‐social) contexts. Concomitant fMRI reveals that oxytocin enhances middle cingulate activity and amygdala connectivity while it modulates network‐level connectivity and attenuates reactivity of a brain ...
Kun Fu, Shuyue Xu, Zheng Zhang, Dan Liu, Ting Xu, Yuan Zhang, Feng Zhou, Xiaodong Zhang, Chunmei Lan, Junjie Wang, Lan Wang, Jingxian He, Keith M Kendrick, Bharat Biswal, Dezhong Yao, Zhen Liang, Weihua Zhao, Benjamin Becker   +17 more
wiley   +1 more source

Emergency Department Utilization and Capacity [PDF]

, 2009
Synthesizes research on who utilizes emergency departments, how often for non-urgent or preventable conditions and why, how cost-sharing affects utilization, and how utilization patterns affect hospital finances, overcrowding, and cost ...
Derek DeLia, Joel Cantor
core  

Multi‐Region Brain Organoids Integrating Cerebral, Mid‐Hindbrain, and Endothelial Systems

Advanced Science, EarlyView.
Multi‐Region Brain Organoids combine cerebral, mid/hindbrain, and endothelial components into an advanced 3D model capturing 80% of fetal brain cellular diversity. This platform reveals essential endothelial‐neural signaling networks that maintain region‐specific intermediate progenitors during hindbrain development.
Anannya Kshirsagar, Hayk Mnatsakanyan, Sai Kulkarni, John Guo, Kai Cheng, Luke Daniel Ofria, Oce Bohra, Ram Sagar, Vasiliki Mahairaki, Christian E Badr, Annie Kathuria   +10 more
wiley   +1 more source

Linking alpha oscillations, attention and inhibitory control in adult ADHD with EEG neurofeedback

NeuroImage: Clinical, 2020
Abnormal patterns of electrical oscillatory activity have been repeatedly described in adult ADHD. In particular, the alpha rhythm (8–12 Hz), known to be modulated during attention, has previously been considered as candidate biomarker for ADHD.
Marie-Pierre Deiber, Roland Hasler, Julien Colin, Alexandre Dayer, Jean-Michel Aubry, Stéphanie Baggio, Nader Perroud, Tomas Ros   +7 more
doaj