Results 91 to 100 of about 4,950,424 (307)

The Cladosporium fulvum Avr2 protein behaves both as a virulence and an avirulence factor [PDF]

, 2010
Plants are not able to move or escape and have to confront environmental challenges like nutrient and water deprivation, low and high temperatures, and biotic stress imposed by pathogens like viruses, bacteria, fungi, nematodes and insects that all ...
van t Klooster, J.W., Klooster, J.W., van t   +1 more
core  

PHI-base: the pathogen-host interactions database. [PDF]

, 2019
The pathogen-host interactions database (PHI-base) is available at www.phi-base.org. PHI-base contains expertly curated molecular and biological information on genes proven to affect the outcome of pathogen-host interactions reported in peer reviewed ...
Wood, V., Yates, A. D., Hassani-Pak, K., Rutherford, K., Pedro, H., Seager, J., De Silva, N., Venkatesh, S. Y, Urban, M., Martinez, M. C., Cuzick, A., Hammond-Kosack, K. E.   +11 more
core   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Susceptibility to Phytophthora ramorum in a key infectious host: Landscape variation in host genotype, host phenotype, and environmental factors [PDF]

, 2008
• Sudden oak death is an emerging forest disease caused by the invasive pathogen Phytophthora ramorum. Genetic and environmental factors affecting susceptibility to P.
Hüberli, D., Gordon, S., Rank, N.E., Harnik, T.Y., Garbelotto, M., Anacker, B.L., Meentemeyer, R., Whitkus, R.   +7 more
core  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Lipidomics of host–pathogen interactions

FEBS Letters, 2006
The cell biology of intracellular pathogens (viruses, bacteria, eukaryotic parasites) has provided us with molecular information of host–pathogen interactions. As a result it is becoming increasingly evident that lipids play important roles at various stages of host–pathogen interactions.
openaire   +2 more sources

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Extending the host range of Listeria monocytogenes by rational protein design [PDF]

, 2007
In causing disease, pathogens outmaneuver host defenses through a dedicated arsenal of virulence determinants that specifically bind or modify individual host molecules. This dedication limits the intruder to a defined range of hosts.
Wollert, Thomas, Gruber, A.D., Heinz, D.W., Pasche, Bastian, van den Heuvel, Joop, Heinz, Dirk W., Lengeling, A., Gruber, Achim D., Heinz, Dirk W, van den Heuvel, J., Schubert, W.D., Rochon, M., Rochon, Maike, Schubert, Wolf-Dieter, Pasche, B., Lengeling, Andreas, Deppenmeier, Stefanie, Deppenmeier, S., Gruber, Achim D, Wollert, T.   +19 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source