Results 111 to 120 of about 4,950,424 (307)

Mycobacterium tuberculosis inhibits METTL14-mediated m6A methylation of Nox2 mRNA and suppresses anti-TB immunity

Cell Discovery
Internal N6-methyladenosine (m6A) modifications are among the most abundant modifications of messenger RNA, playing a critical role in diverse biological and pathological processes.
Mingtong Ma, Yongjia Duan, Cheng Peng, You Wu, Xinning Zhang, Boran Chang, Fei Wang, Hua Yang, Ruijuan Zheng, Hongyu Cheng, Yuanna Cheng, Yifan He, Jingping Huang, Jinming Lei, Hanyu Ma, Liru Li, Jie Wang, Xiaochen Huang, Fen Tang, Jun Liu, Jinsong Li, Ruoyan Ying, Peng Wang, Wei Sha, Yawei Gao, Lin Wang, Baoxue Ge   +26 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

The role of the AHR in host–pathogen interactions

Nature Reviews Immunology
Host-microorganism encounters take place in many different ways and with different types of outcomes. Three major types of microorganisms need to be distinguished: (1) pathogens that cause harm to the host and must be controlled; (2) environmental microorganisms that can be ignored but must be controlled at higher abundance; and (3) symbiotic ...
Palmira Barreira-Silva, Yilong Lian, Stefan H. E. Kaufmann, Pedro Moura-Alves   +3 more
openaire   +5 more sources

DNA barcoding and blood meal profiling of Ethiopian mosquitoes (Diptera: Culicidae): insights into species identification and host preferences

Parasites & Vectors
Background Arboviruses continue to threaten global health because of their rapid geographical expansion and significant disease burden. Of the over 500 recognized arboviruses, approximately 150 affect humans, and around 50 affect domestic animals and ...
Samson Leta, Tesfaye Mulatu, Bekele Yalew, Tesfaye Rufael Chibssa, Jan Paeshuyse   +4 more
doaj   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

A Host-Host-Pathogen Model with Vaccination and its Application to Target and Reservoir Hosts [PDF]

, 2007
A simple theoretical framework is presented that addresses the question of how different vaccination strategies work against a pathogen which infects two species.
Norman, Rachel, R. G. Bowers, R. Norman, Bowers, Roger   +3 more
core   +1 more source

Design, synthesis and evaluation of antifungal activity of 8-hydroxyquinolin-5-ylidene thiosemicarbazone derivatives

Current Research in Microbial Sciences
Over the past decades, the incidence and modality of invasive fungal infections have been significantly underestimated. And the limited availability of clinically effective antifungals further underscores the need for novel therapeutic agents.
Haonan Zhang, Xiaochen Chi, Zhe Ji, Jiayin Wang, Futang Liu, Nan Chen, Qingli Guo, Yuanying Jiang, Tingjunhong Ni   +8 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus [PDF]

, 2014
Several bacterial pathogens decorate their surfaces with sialic acid (Sia) residues within cell wall components or capsular exopolysaccharides. Sialic acid expression can promote bacterial virulence by blocking complement activation or by engagement of ...
Joshua Olson, Louie, Aaron, Crocker, Paul R., Victor Nizet, Aaron Louie, Ajit Varki, Paul R. Crocker, Varki, Ajit, Nizet, Victor, Yung-Chi Chang, Chang, Yung-Chi, Olson, Joshua   +11 more
core   +1 more source

Host Immune Response to Bovine Viral Diarrhea Virus (BVDV): Insights and Strategies for Effective Vaccine Design

Vaccines
Bovine viral diarrhea (BVD) is caused by bovine viral diarrhea virus (BVDV), a member of the genus Pestivirus and in the family Flaviviridae. According to some studies, the disease incurs USD 1.5–2.5 billion per year and USD 0.50 to USD 687.80 per cow ...
Asamenew Tesfaye Melkamsew, Tesfaye Sisay Tessema, Jan Paeshuyse   +2 more
doaj   +1 more source