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Hologenomics: Systems-Level Host Biology [PDF]

mSystems, 2018
The hologenome concept of evolution is a hypothesis explaining host evolution in the context of the host microbiomes. As a hypothesis, it needs to be evaluated, especially with respect to the extent of fidelity of transgenerational coassociation of host ...
Kevin R. Theis
doaj   +5 more sources

Advanced Multiplex Loop Mediated Isothermal Amplification (mLAMP) Combined with Lateral Flow Detection (LFD) for Rapid Detection of Two Prevalent Malaria Species in India and Melting Curve Analysis

Diagnostics, 2021
Isothermal techniques with lateral flow detection have emerged as a point of care (POC) technique for malaria, a major parasitic disease in tropical countries such as India.
Supriya Sharma, Sandeep Kumar, Md Zohaib Ahmed, Nitin Bhardwaj, Jaskirat Singh, Sarita Kumari, Deepali Savargaonkar, Anupkumar R. Anvikar, Jyoti Das   +8 more
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Nationwide spatiotemporal drug resistance genetic profiling from over three decades in Indian Plasmodium falciparum and Plasmodium vivax isolates

Malaria Journal, 2023
Background Drug resistance is a serious impediment to efficient control and elimination of malaria in endemic areas. Methods This study aimed at analysing the genetic profile of molecular drug resistance in Plasmodium falciparum and Plasmodium vivax ...
Loick P. Kojom Foko, Geetika Narang, Jahnvi Jakhan, Suman Tamang, Amit Moun, Vineeta Singh   +5 more
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The spectrum of clinical biomarkers in severe malaria and new avenues for exploration

Virulence, 2022
Globally, malaria is a public health concern, with severe malaria (SM) contributing a major share of the disease burden in malaria endemic countries. In this context, identification and validation of SM biomarkers are essential in clinical practice. Some
Loick Pradel Kojom Foko, Geetika Narang, Suman Tamang, Joseph Hawadak, Jahnvi Jakhan, Amit Sharma, Vineeta Singh   +6 more
doaj   +1 more source

Pathophysiology of Cerebral Malaria: Implications of MSCs as A Regenerative Medicinal Tool

Bioengineering, 2022
The severe form of malaria, i.e., cerebral malaria caused by Plasmodium falciparum, is a complex neurological syndrome. Surviving persons have a risk of behavioral difficulties, cognitive disorders, and epilepsy.
Amrendra Chaudhary, Poonam Kataria, Neha Surela, Jyoti Das   +3 more
doaj   +1 more source

AN ESTERASE-LIKE PROTEIN (ELP) CONFERRED MALATHION AND DELTAMETHRIN RESISTANCE IN THE INDIAN FIELD POPULATION OF ANOPHELES STEPHENSI

International Journal of Infectious Diseases, 2023
Intro: Chemical insecticides in the form of IRS (Indoor Residual Sprays) and LLITNs (Long Lasting Insecticide Treated Nets) comprise current malaria vector control strategies.
J. Kumar, K. Prasad, V. Kumari, K. Pandey   +3 more
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CD4+ICOS+Foxp3+: a sub-population of regulatory T cells contribute to malaria pathogenesis

Malaria Journal, 2022
Background Regulatory T cells are known to play a key role to counter balance the protective immune response and immune mediated pathology. However, the role of naturally occurring regulatory cells CD4+CD25+Foxp3 + in malaria infection during the disease
Rubika Chauhan, Vikky Awasthi, Reva Sharan Thakur, Veena Pande, Debprasad Chattopadhyay, Jyoti Das   +5 more
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Comodulation of Dengue and Chikungunya Virus Infection During a Coinfection Scenario in Human Cell Lines

Frontiers in Cellular and Infection Microbiology, 2022
The Dengue virus (DENV) and Chikungunya virus (CHIKV) are the arboviruses that pose a threat to global public health. Coinfection and antibody-dependent enhancement are major areas of concern during DENV and CHIKV infections, which can alter the clinical
Debjani Taraphdar, Bharati Singh, Bharati Singh, Sabyasachi Pattanayak, Avula Kiran, Avula Kiran, Poornima Kokavalla, Mohd. Faraz Alam, Mohd. Faraz Alam, Gulam Hussain Syed   +9 more
doaj   +1 more source

IL-10 Producing Regulatory B Cells Mediated Protection against Murine Malaria Pathogenesis

Biology, 2022
Various immune cells are known to participate in combating infection. Regulatory B cells represent a subset of B cells that take part in immunomodulation and control inflammation.
Meenu Kalkal, Rubika Chauhan, Reva Sharan Thakur, Mrinalini Tiwari, Veena Pande, Jyoti Das   +5 more
doaj   +1 more source

ROLE OF METACASPASE IN MALARIA TRANSMISSION BIOLOGY

International Journal of Infectious Diseases, 2023
Intro: A family of apicomplexan-specific proteins contains caspases–like proteins called “metacaspases”. These enzymes are present in the malaria parasite but absent in human, therefore, these can be explored as potential drug targets to combat malaria ...
K. Pandey, V. Kumari, K. Prasad, I.K. Kalia, G. Sindhu, R. Dixit, D. Rawat, O. Singh, A. Singh   +8 more
doaj   +1 more source