Results 111 to 120 of about 3,883,661 (304)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Heterogeneity of Salmonella-host interactions in infected host tissues [PDF]

, 2017
Infected host tissues have complex anatomy, diverse cell types, and dynamic inflammation. Traditional infection biology approaches largely ignore this complex host environment and its impact on pathogens, but recent single-cell technologies unravel ...
Olivier Cunrath, Bumann, Dirk, Dirk Bumann, Cunrath, Olivier, Bumann D, Cunrath O   +5 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The biotechnological potential of proteases from hematophagous arthropod vectors

Frontiers in Cellular and Infection Microbiology, 2023
Carla Nunes de Araújo, Carla Nunes de Araújo, Paula Beatriz Santiago, Giulia Causin Vieira, Gabriel dos Santos Silva, Renan Pereira Moura, Izabela Marques Dourado Bastos, Jaime Martins de Santana   +7 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A virulent strain of deformed wing virus (DWV) of honeybees (Apis mellifera) prevails after varroa destructor-mediated, or in vitro, transmission [PDF]

, 2014
The globally distributed ectoparasite Varroa destructor is a vector for viral pathogens of the Western honeybee (Apis mellifera), in particular the Iflavirus Deformed Wing Virus (DWV).
James C Bull, Jonathan D. Moore (262014), Fannon, Jessica, Jonathan D. Moore, Dave Ch, Graham R Wood, James C. Bull¤a, Fannon, Jessica M., Jessica M Fannon, Mead, Andrew, Jessica M. Fannon (589359), James C. Bull (107677), Nigel Burroughs (589360), David J. Evans (208308), Graham R. Wood, Nigel Burroughs, David J. Evans, Ryabov, Eugene V., Wood, Graham R., Chandler, Dave, Eugene V. Ryabov (107680), Mead, A. (Andrew), Eugene V Ryabov, Andrew Mead, David J Evans, Jonathan D Moore, Moore, Jonathan D., Wood, Graham, Bull, James C., Burroughs, Nigel, Graham R. Wood (589358), Dave Chandler (107700), Dave Chandler, Jessica M. Fannon, Andrew Mead (107686), Bull, James C. (James Christopher), Burroughs, Nigel John, Evans, David J., Eugene V. Ryabov, Bull James C., Burroughs Nigel, Evans David J., Moore Jonathan D., Chandler Dave, Ryabov Eugene V., James Bull, Mead Andrew, Wood Graham R., Fannon Jessica M., Evans, David J.; id_orcid   +49 more
core   +2 more sources

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Glochidia ecology in wild fish populations and laboratory determination of competent host fishes for an endemic freshwater mussel of south-western Australia [PDF]

, 2012
Glochidia (parasitic larvae) of freshwater mussels generally require a fish as a host. Westralunio carteri Iredale, 1934 (Bivalvia : Hyriidae), the only freshwater mussel found in south-western Australia, was listed as Vulnerable, but recently changed to
Morgan, David L, Lymbery, Alan J, Thomson, G.J., Beatty, Stephen J, Klunzinger, M.W., Lymbery, A.J., Beatty, S.J., Morgan, D.L., Klunzinger, Michael W, Thomson, Gordon J   +9 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source