Results 91 to 100 of about 1,352,426 (310)
, 2017 Improvements in sequencing technologies and reduced experimental costs have resulted in a vast number of studies generating high-throughput data. Although the number of methods to analyze these "omics" data has also increased, computational complexity ...
A Fuente de la +56 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Differing Host Exploitation Efficiencies in Two Hyperparasitoids: When is a ‘Match Made in Heaven’? [PDF]
, 2011 Host exploitation behavior in two hyperparasitoids, Lysibia nana and Gelis agilis, was compared in single cocoon clusters of their primary parasitoid host, Cotesia glomerata. L.
Harvey, J.A., Wagenaar, R., Gols, R.
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Description of a new Crossidius LeConte (Coleoptera: Cerambycidae: Cerambycinae: Trachyderini) from southern Georgia with comments on its biology and unusual distribution [PDF]
, 2013 Crossidius grahami Morris and Wappes new species (Coleoptera: Cerambycidae) is described from the Ohoopee Dunes of southern Georgia. Comments are included on the new species’ biology and disjunct distribution compared to other species of Crossidius ...
Morris, Roy F., Wappes, James E.
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Polymorphism and danger susceptibility of system call DASTONs [PDF]
, 2007 We have proposed a metaphor “DAnger Susceptible daTa codON� (DASTON) in data subject to processing by Danger Theory (DT) based Artificial Immune System (DAIS).
Iqbal, Anjum, Maarof, Mohd. Aizaini
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Numerical study of a three-state host-parasite system on the square lattice
, 2011 We numerically study the phase diagram of a three-state host-parasite model on the square lattice motivated by population biology. The model is an extension of the contact process, and the three states correspond to an empty site, a host, and a parasite.
Hasegawa, Takehisa +2 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
BMC Infectious Diseases, 2019 Background Blood culture bottles (BCBs) provide a semiautomated method for culturing periprosthetic tissue specimens. A study evaluating BCBs for culturing clinical samples other than body fluids is needed before implementation into clinical practice ...
Adriana Sanabria +5 more
doaj +1 more source