Results 71 to 80 of about 1,352,426 (310)

Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling. [PDF]

, 2014
One challenge in biology is signal transduction monitoring in a physiological context. Intravital imaging techniques are revolutionizing our understanding of tumor and host cell behaviors in the tumor environment.
Bonora, M, Giorgi, C, Mammano, Fabio, Missiroli, S, Morciano, G, Morganti, C, Pandolfi, Pp, Pinton, P., Poletti, F, Ramirez, Fg   +9 more
core   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The endosymbiont Spiroplasma poulsonii increases Drosophila melanogaster resistance to pathogens by enhancing iron sequestration and melanization

mBio
Facultative endosymbiotic bacteria, such as Wolbachia and Spiroplasma species, are commonly found in association with insects and can dramatically alter their host physiology.
Alexandra Hrdina, Marina Serra Canales, Aranzazu Arias-Rojas, Dagmar Frahm, Igor Iatsenko   +4 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

In Silico Approaches for the Identification of Aptamer Binding Interactions to Leptospira spp. Cell Surface Proteins

Tropical Medicine and Infectious Disease, 2023
Aptamers are nucleic acids that can bind with high affinity and specificity to a range of target molecules. However, their functionality relies on their secondary and tertiary structures such that the combination of nucleotides determines their three ...
Chembie A. Almazar, Marjo V. Mendoza, Windell L. Rivera   +2 more
doaj   +1 more source

Effects of disorder on the wave front depinning transition in spatially discrete systems [PDF]

, 2002
Pinning and depinning of wave fronts are ubiquitous features of spatially discrete systems describing a host of phenomena in physics, biology, etc. A large class of discrete systems is described by overdamped chains of nonlinear oscillators with nearest ...
A. Carpio, A. Carpio, A. Carpio, A. Luzón, A.A. Middleton, A.E. Bugrim, D.S. Fisher, D.S. Fisher, G. Grüner, H.S.J. van der Zant, J. Frenkel, J.P. Keener, L. L. Bonilla, L.L. Bonilla, L.L. Bonilla, M. Löcher, O.M. Braun   +16 more
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Genetic variability in the sdrD gene in Staphylococcus aureus from healthy nasal carriers

BMC Microbiology, 2018
Background Staphylococcus aureus cell wall anchored Serine Aspartate repeat containing protein D (SdrD) is a member of the microbial surface component recognising adhesive matrix molecules (MSCRAMMs).
Clement Ajayi, Espen Åberg, Fatemeh Askarian, Johanna U. E. Sollid, Mona Johannessen, Anne-Merethe Hanssen   +5 more
doaj   +1 more source

Microbial communities and bioactive compounds in marine sponges of the family Irciniidae-a review [PDF]

, 2014
Marine sponges harbour complex microbial communities of ecological and biotechnological importance. Here, we propose the application of the widespread sponge family Irciniidae as an appropriate model in microbiology and biochemistry research. Half a gram
Anand, Asano, Bandara, Bayer, Bringmann, Brochier-Armanet, Cardoso, Cook, Cook, Cristiane Hardoim, De Caralt, De Rosa, De Rosa, De Rosa, De Rosa, De Voogd, Degrassi, di Camillo, Dieckmann, Dobretsov, Duckworth, Duckworth, Enticknap, Ereskovsky, Erwin, Erwin, Erwin, Esteves, Fan, Fan, Fieseler, Fiore, Fisch, Flemer, Friedrich, Gaino, Han, Hardoim, Hardoim, Hardoim, Hentschel, Hentschel, Hentschel, Hentschel, Hochmuth, Hoffmann, Hoffmann, Holden, Höller, Isaacs, Jaeckle, Kalia, Kalinovskaya, Kamke, Kamke, Lee, Lee, Lee, Li, Lindquist, Liu, Lopanik, Lopanik, Lopanik, Lopanik, Love, Luter, Maldonado, Man-Aharonovich, Mohamed, Mohamed, Mohamed, Mohamed, Mohamed, Muscholl-Silberhorn, Osinga, O’Halloran, Pantile, Paz, Pester, Piel, Piel, Pita, Pita, Pita, Prokof'eva, Rinkevich, Rodrigo Costa, Sara, Schirmer, Schmitt, Schmitt, Schmitt, Sharp, Siegl, Siegl, Simister, Simister, Simister, Skindersoe, Spalding, Spang, Stabili, Staunton, Sudek, Tabares, Taylor, Taylor, Thakur, Thakur, Thiel, Thomas, Thomas, Usher, Usher, Vacelet, Van Soest, Van Treeck, Webster, Webster, Webster, Webster, Webster, Webster, Webster, Webster, Weisz, Wilkinson, Wilkinson, Wilkinson, Wilkinson, Wulff, Wörheide, Yang, Zan, Zehr, Zehr   +136 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source