Results 81 to 90 of about 3,883,661 (304)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Increased migration in host–pathogen metapopulations can cause host extinction

, 2012
There are at least two potentially counteracting effects of migration in host–pathogen metapopulations. On the one hand increased migration leads to increased colonization of empty habitats by healthy hosts; on the other hand migrants can carry ...
Wennberg, Bernt, Begon, M., Wennberg, Bernt,, Begon, M.,, Harding, Karin C., Harding, Karin C.,, Eriksson, Anders, Eriksson, Anders,   +7 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Genetic variability in parasites and host-parasite interactions [PDF]

, 1996
We have examined genetic variability in parasites in the context of ecological interactions with the host. Recent research on Echinococcus, Giardia and Cryptosporidium has been used to illustrate: (i) the problems that parasite variability and species ...
Thompson, R.C.A., Lymbery, A.J.
core  

Candidalysin biology and activation of host cells

mBio
ABSTRACT Candida albicans is an opportunistic fungal pathogen that can cause life-threatening systemic infections and distressing mucosal infections. A major breakthrough in understanding C.
Léa Lortal, Claire M. Lyon, Jakob L. Sprague, Johannes Sonnberger, Olivia K. A. Paulin, Don N. Wickramasinghe, Jonathan P. Richardson, Bernhard Hube, Julian R. Naglik   +8 more
openaire   +3 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The Irish potato famine pathogen Phytophthora infestans translocates the CRN8 kinase into host plant cells [PDF]

, 2012
Phytopathogenic oomycetes, such as Phytophthora infestans, secrete an arsenal of effector proteins that modulate plant innate immunity to enable infection. We describe CRN8, a host-translocated effector of P. infestans that has kinase activity in planta.
Cakir, Cahid, Tolga O Bozkurt, Sebastian Schornack, Cahid Cakir, Mireille van Damme, Cahid Cakir (142118), Bozkurt, Tolga O, Kamoun, S., Kamoun, Sophien, Jones, A.M.E., Sklenar, Jan, Sophien Kamoun (6132), Cakir, C., Schornack, S., Schornack, Sebastian, van Damme, Mireille, Jan Sklenar (142122), Jones, Alexandra ME, Jones, Alexandra M., Mireille van Damme (142110), Tolga O. Bozkurt (142114), Bozkurt, Tolga O., Sophien Kamoun, Bozkurt, T.O., Sklenar, J., Alexandra M. E. Jones (50010), Alexandra M E Jones, Damme, M., van, Sebastian Schornack (142120), Jan Sklenar   +29 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source