Results 51 to 60 of about 652,566 (312)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Prolyl Oligopeptidase From Leishmania infantum: Biochemical Characterization and Involvement in Macrophage Infection

Frontiers in Microbiology, 2020
Leishmania infantum is a flagellated protozoan and one of the main causative agents of visceral leishmaniasis. This disease usually affects the human reticuloendothelial system, can cause death and available therapies may lead to serious side effects ...
Camila Lasse, Clênia S. Azevedo, Clênia S. Azevedo, Carla N. de Araújo, Carla N. de Araújo, Flávia N. Motta, Flávia N. Motta, Milene A. Andrade, Milene A. Andrade, Amanda Pereira Rocha, Iracyara Sampaio, Sébastien Charneau, Marc Gèze, Marc Gèze, Philippe Grellier, Jaime M. Santana, Izabela M. D. Bastos   +16 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Host-pathogen systems biology: logical modelling of hepatocyte growth factor and induced c-Met signal transduction-7

, 2011
Copyright information:Taken from "Host-pathogen systems biology: logical modelling of hepatocyte growth factor and induced c-Met signal transduction"http://www.biomedcentral.com/1752-0509/2/4BMC Systems Biology 2008;2():4-4.Published online 14 Jan ...
Steffen Klamt (25228), Nicole Wundrack (87887), Michael Naumann (87890), Thilo Kähne (87889), Ernst-Dieter Gilles (87888), Melanie Müller (37533), Raimo Franke (87886)   +6 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural insights into the mechanism of archaellar rotational switching

Nature Communications, 2022
Signal transduction via phosphorylated CheY is conserved in bacteria and archaea. In this study, the authors employ structural biochemistry combined with cell biology to delineate the mechanism of CheY recognition by the adaptor protein CheF.
Florian Altegoer, Tessa E. F. Quax, Paul Weiland, Phillip Nußbaum, Pietro I. Giammarinaro, Megha Patro, Zhengqun Li, Dieter Oesterhelt, Martin Grininger, Sonja-Verena Albers, Gert Bange   +10 more
doaj   +1 more source

Library-independent source tracking of fecal contamination in selected stations and tributaries of Laguna Lake, Philippines

Journal of Water and Health, 2021
Laguna Lake is the largest inland freshwater body in the Philippines. Although it is classified to be usable for agricultural and recreational purposes by the country's Department of Environment and Natural Resources (DENR), studies looking at lake ...
Joseth Jermaine M. Abello, Gicelle T. Malajacan, Kevin L. Labrador, Mae Ashley G. Nacario, Luiza H. Galarion, Marie Christine M. Obusan, Windell L. Rivera   +6 more
doaj   +1 more source

Cell biology of Candida albicans–host interactions

Current Opinion in Microbiology, 2016
Candida albicans is a commensal coloniser of most people and a pathogen of the immunocompromised or patients in which barriers that prevent dissemination have been disrupted. Both the commensal and pathogenic states involve regulation and adaptation to the host microenvironment.
Da Silva Dantas, Alessandra, LEE, Kathy K, Raziunaite, Ingrida, Schaefer, Katja, Wagener, Jeanette, Yadav, Bhawna, Gow, Neil Andrew Robert   +6 more
openaire   +3 more sources

Differential expression of immune defences is associated with specific host-parasite interactions in insects [PDF]

, 2009
Recent ecological studies in invertebrates show that the outcome of an infection is dependent on the specific pairing of host and parasite. Such specificity contrasts the long-held view that invertebrate innate immunity depends on a broadspectrum ...
Carolyn Riddell, Riddell, Carolyn, Eamonn B. Mallon (7514327), Adams, Sally, Sally Adams, Schmid-Hempel, Paul, Mallon Eamonn B., Schmid-Hempel Paul, Carolyn Riddell (257705), Paul Schmid-Hempel, S. Adams (1469704), Mallon, Eamonn B., Eamonn B Mallon, Adams Sally, Riddell Carolyn, Ridell, Carolyn, P. Schmid-Hempel (7607216)   +16 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source