Results 41 to 50 of about 551,921 (295)

High levels of third-stage larvae (L3) overwinter survival for multiple cattle gastrointestinal nematode species on western Canadian pastures as revealed by ITS2 rDNA metabarcoding

Parasites & Vectors, 2020
Background The ability of infective larvae of cattle gastrointestinal nematode (GIN) species to overwinter on pastures in northerly climatic zones with very cold dry winters is poorly understood.
Tong Wang, Russell W. Avramenko, Elizabeth M. Redman, Janneke Wit, John S. Gilleard, Douglas D. Colwell   +5 more
doaj   +1 more source

High-level integration of murine intestinal transcriptomics data highlights the importance of the complement system in mucosal homeostasis

BMC Genomics, 2019
Background The mammalian intestine is a complex biological system that exhibits functional plasticity in its response to diverse stimuli to maintain homeostasis.
Nirupama Benis, Jerry M. Wells, Mari A. Smits, Soumya Kanti Kar, Bart van der Hee, Vitor A. P. Martins dos Santos, Maria Suarez-Diez, Dirkjan Schokker   +7 more
doaj   +1 more source

Detection of the infective Plasmodium falciparum gametocytes by RT-qPCR assay from a malaria-endemic region of Northeastern India

Frontiers in Tropical Diseases
IntroductionThe diagnosis of infectious reservoirs in malaria (gametocytes) is necessary, especially in low-density infections and asymptomatic malaria patients. The gametocyte stage is a surrogate marker for infection of P. falciparum malaria in healthy
Ram Das, Kapil Vashisht, Lokesh Kori, Kuldeep Singh, Gaurav Kumar, Izazul Hasan, Jugal Gam, Kailash C. Pandey   +7 more
doaj   +1 more source

Unraveling dual feeding associated molecular complexity of salivary glands in the mosquito Anopheles culicifacies

Biology Open, 2015
Mosquito salivary glands are well known to facilitate meal acquisition, however the fundamental question on how adult female salivary gland manages molecular responses during sugar versus blood meal uptake remains unanswered.
Punita Sharma, Swati Sharma, Ashwani Kumar Mishra, Tina Thomas, Tanwee Das De, Suman Lata Rohilla, Namita Singh, Kailash C. Pandey, Neena Valecha, Rajnikant Dixit   +9 more
doaj   +1 more source

Prolyl Oligopeptidase From Leishmania infantum: Biochemical Characterization and Involvement in Macrophage Infection

Frontiers in Microbiology, 2020
Leishmania infantum is a flagellated protozoan and one of the main causative agents of visceral leishmaniasis. This disease usually affects the human reticuloendothelial system, can cause death and available therapies may lead to serious side effects ...
Camila Lasse, Clênia S. Azevedo, Clênia S. Azevedo, Carla N. de Araújo, Carla N. de Araújo, Flávia N. Motta, Flávia N. Motta, Milene A. Andrade, Milene A. Andrade, Amanda Pereira Rocha, Iracyara Sampaio, Sébastien Charneau, Marc Gèze, Marc Gèze, Philippe Grellier, Jaime M. Santana, Izabela M. D. Bastos   +16 more
doaj   +1 more source

Network topology drives population temporal variability in experimental habitat networks

Population Ecology, EarlyView.
Habitat patches connected by dispersal pathways form habitat networks. We explored how network topology affects population outcomes in laboratory experiments using a model species (Daphnia carinata). Central habitat nodes in complex lattice networks exhibited lower temporal variability in population sizes, suggesting they support more stable ...
Yiwen Xu, J. Angus Webb, William D. Bovill, Elise L. King   +3 more
wiley   +1 more source

ROLE OF METACASPASE IN MALARIA TRANSMISSION BIOLOGY

International Journal of Infectious Diseases, 2023
Intro: A family of apicomplexan-specific proteins contains caspases–like proteins called “metacaspases”. These enzymes are present in the malaria parasite but absent in human, therefore, these can be explored as potential drug targets to combat malaria ...
K. Pandey, V. Kumari, K. Prasad, I.K. Kalia, G. Sindhu, R. Dixit, D. Rawat, O. Singh, A. Singh   +8 more
doaj  

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source